|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD.
|
23404241 |
2013 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5-HT2A C102T silent polymorphism and suicidality in patients with major depression.
|
17221840 |
2007 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We did not detect significant an association of HTR2A with MDD and BP in allele/genotype-wise or haplotype-wise analysis.
|
19428704 |
2009 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine the relationship between the -1438A/G polymorphism in the 5-HTR2A gene and the response to citalopram in a Korean population with major depressive disorder (MDD).
|
16127283 |
2005 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients.
|
19937159 |
2010 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pharmacological studies have yielded valuable insights into the role of the serotonin 2A (5-HT2A) receptor in major depressive disorder (MDD) and antidepressant drugs (ADs) response.
|
26764241 |
2016 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that the 5-HTR2A rs6313 T>C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR=1.33, 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-2.18, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008).
|
25108775 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, two single nucleotide polymorphisms of the HTR2A gene (rs6314 ie His452Tyr and rs6313 ie rs6313" genes_norm="3356">102C/T), which specific allelic variants may decrease 5-HT2AR-mediated transmission (as in Htr2a(-/-)mice), were studied in a sample of 485 Caucasian patients with MDD.
|
24801750 |
2014 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD.
|
23547754 |
2013 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)].
|
25990886 |
2015 |
|
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.
|
14744462 |
2004 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression.
|
15469201 |
2004 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder.
|
12422060 |
2002 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To explore the possible relationship between six single nucleotide polymorphisms (SNPs) (rs6311 and rs6305 of 5-HT2A, rs5443 of Gβ3, rs2230739 of ACDY9, rs1549870 of PDE1A and rs255163 of CREB1, which are all related with 5-HT2A the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (SSRI) treatments in major depressive disorder (MDD) Chinese.
|
22480177 |
2012 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
|
21136126 |
2010 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
|
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
While further work is needed to identify the actual functional genetic variants involved, these results suggest that a relationship exists between genetic variation in HTR2A and either 5-HTT expression or central serotonergic transmission that influences the therapeutic response to 5-HTT inhibition in major depression.
|
20047709 |
2010 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD.
|
19897250 |
2009 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Our findings suggested that the 5-HTR2A rs6313 T>C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR=1.33, 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-2.18, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008).
|
25108775 |
2014 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000.
|
10686553 |
2000 |