Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Our results demonstrate the influence of a HTR2A polymorphism on aspects of somatization in major depression, which co-occurs with an unfavorable antidepressant treatment outcome. 21838737 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients. 19937159 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression. 21136126 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 AlteredExpression disease BEFREE While further work is needed to identify the actual functional genetic variants involved, these results suggest that a relationship exists between genetic variation in HTR2A and either 5-HTT expression or central serotonergic transmission that influences the therapeutic response to 5-HTT inhibition in major depression. 20047709 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE We did not detect significant an association of HTR2A with MDD and BP in allele/genotype-wise or haplotype-wise analysis. 19428704 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD. 19897250 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. 19590397 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE These results support the hypothesis that GNB3, HTR2A, and SLC6A4 may play a role in the outcome of short-term antidepressant treatment for MDD in an interactive manner. 19560507 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5-HT2A C102T silent polymorphism and suicidality in patients with major depression. 17221840 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE The purpose of this study was to determine the relationship between the -1438A/G polymorphism in the 5-HTR2A gene and the response to citalopram in a Korean population with major depressive disorder (MDD). 16127283 2005
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 AlteredExpression disease BEFREE Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. 14744462 2004
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression. 15469201 2004
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Our results support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population. 14730199 2004
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. 12851635 2003
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Specifically, homozygous carriers of the 5-HT2A C102 allele were five times more likely to have major depressive illness than heterozygotes. 12707936 2003
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder. 12422060 2002
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE The 102T/C polymorphism of the 5-HT(2A) receptor gene was analyzed in 159 patients with major depression (DSM-IV criteria) and 164 unrelated and healthy controls using a case control design. 11803534 2001
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Overall our results suggest that the investigated 5-HT2A and 5-HTTLPR polymorphisms are not major susceptibility factors in the etiology of major depression. 11311507 2001
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE These results suggest that variation in the 5-HT2A receptor gene may play a role in the development of major depression with seasonal pattern and support the existence of a genetic and etiological heterogeneity underlying the diagnosis of major depression. 11317230 2001
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000. 10686553 2000
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression. 11121191 2000
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease CTD_human