Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate the influence of a HTR2A polymorphism on aspects of somatization in major depression, which co-occurs with an unfavorable antidepressant treatment outcome.
|
21838737 |
2011 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients.
|
19937159 |
2010 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
|
21136126 |
2010 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
While further work is needed to identify the actual functional genetic variants involved, these results suggest that a relationship exists between genetic variation in HTR2A and either 5-HTT expression or central serotonergic transmission that influences the therapeutic response to 5-HTT inhibition in major depression.
|
20047709 |
2010 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We did not detect significant an association of HTR2A with MDD and BP in allele/genotype-wise or haplotype-wise analysis.
|
19428704 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the HTR2A gene, were studied in 420 patients with MD to investigate the relationship between these genes and suicidal ideation in MD.
|
19897250 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results support the hypothesis that GNB3, HTR2A, and SLC6A4 may play a role in the outcome of short-term antidepressant treatment for MDD in an interactive manner.
|
19560507 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The serotonin 2A (5-HT2A) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5-HT2A C102T silent polymorphism and suicidality in patients with major depression.
|
17221840 |
2007 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine the relationship between the -1438A/G polymorphism in the 5-HTR2A gene and the response to citalopram in a Korean population with major depressive disorder (MDD).
|
16127283 |
2005 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.
|
14744462 |
2004 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression.
|
15469201 |
2004 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.
|
14730199 |
2004 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques.
|
12851635 |
2003 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Specifically, homozygous carriers of the 5-HT2A C102 allele were five times more likely to have major depressive illness than heterozygotes.
|
12707936 |
2003 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder.
|
12422060 |
2002 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The 102T/C polymorphism of the 5-HT(2A) receptor gene was analyzed in 159 patients with major depression (DSM-IV criteria) and 164 unrelated and healthy controls using a case control design.
|
11803534 |
2001 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overall our results suggest that the investigated 5-HT2A and 5-HTTLPR polymorphisms are not major susceptibility factors in the etiology of major depression.
|
11311507 |
2001 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that variation in the 5-HT2A receptor gene may play a role in the development of major depression with seasonal pattern and support the existence of a genetic and etiological heterogeneity underlying the diagnosis of major depression.
|
11317230 |
2001 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000.
|
10686553 |
2000 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression.
|
11121191 |
2000 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|