HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R). 31711155 2020
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Depression may be associated with altered serotonergic function in the auditory cortex involving the 5-HT2A receptor and is part of a wider view of the pathophysiology of mood disorders extending beyond psychopathology. 31120232 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE They may play a role in depression through an ability of 5-HT2A protomer signaling to inhibit the 5-HT1A protomer recognition and signaling. 29865267 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE It also provided evidence that 5-HTR2A mRNA levels in PBMCs of MDD patients could be associated with the severity of depression and the duration of the illness. 28125323 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE It is proposed that the demonstrated 5-HT1A-5-HT2A isoreceptor complexes may play a role in depression through integration of 5-HT recognition, signaling and trafficking in the plasma membrane in two major 5-HT receptor subtypes known to be involved in depression. 28920103 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Previous studies have identified SLC6A4 and HTR2A associations with SSRI response in patients with depression and 5-HTTLPR (SLC6A4) associations with escitalopram response in ASD. 26262902 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Associations between suicidal ideation and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, and 5-HTR2a 102T/C genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method after adjustment for potential covariates, including depression. 23973249 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE The frontal abnormality of patients with depression had certain 5-HT genetic basis, and 5-HT2A receptor CC allele and MAOA-H genotype had synergistic effect on the activity abnormality when recognizing negative emotion in right frontal middle gyrus of patients with depression. 24314147 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET The frontal abnormality of patients with depression had certain 5-HT genetic basis, and 5-HT2A receptor CC allele and MAOA-H genotype had synergistic effect on the activity abnormality when recognizing negative emotion in right frontal middle gyrus of patients with depression. 24314147 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Associations between suicidal ideation and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, and 5-HTR2a 102T/C genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method after adjustment for potential covariates, including depression. 23973249 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome. 23537781 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Targeted analysis of HTR2A in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study reveals associations between functional variants and depression severity or citalopram response. 23158458 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Targeted analysis of HTR2A in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study reveals associations between functional variants and depression severity or citalopram response. 23158458 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome. 23537781 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE This study aimed to investigate whether polymorphisms of interest in 5-HTT, 5-HTR2a, and BDNF genes are associated with depression after mastectomy for breast cancer. 22210241 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE SNPs in HTR2A were associated with both pain phenotypes in the discovery cohort, and a number of these SNP associations were replicated in the validation cohort, some of which were attenuated after adjustment for depression. 21305503 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R). 20383137 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE Alterations in the constitutive activity of 5-HT(2A) and 5-HT(2C) receptor systems could be involved in the mechanisms underlying anxiety and depression or exploited for therapeutic benefit. 18772038 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE 5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine. 18801406 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men. 16806099 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Reports have shown an association of a serotonin-2A receptor (HTR2A) gene T102C polymorphism with AD + P and with depression during AD. 17525976 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE The HTR2A gene may be involved in the development of depression by influencing how individuals respond to environmental conditions. 17510953 2007