HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 GeneticVariation disease BEFREE Nominal associations that did not survive correction for multiple testing were observed for NPSR1 rs324891 (T allele: OR=1.22, 95% CI: 1.07-1.38, P=0.002), TPH1 rs1800532 (AA genotype: OR=1.46, 95% CI: 1.14-1.89, P=0.003) and HTR2A rs6313 (T allele: OR=1.19, 95% CI: 1.07-1.33, P=0.002) in studies with samples of European ancestry and for MAOA-uVNTR in female PD (low-active alleles: OR=1.21, 95% CI: 1.07-1.38, P=0.004). 26390831 2016
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 GeneticVariation disease BEFREE The aim of this study was to investigate the genotype distribution of the COMT val158met and 5HTR2A 102T/C polymorphisms in PD. 22036916 2012
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 Biomarker disease BEFREE The aim of this study is to evaluate the association between HTR1A, HTR2A and the 5-HTTLPR in panic disorder (PD) patients and controls. 20817074 2010
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 GeneticVariation disease BEFREE This result suggests that 5HTR2A 1438A/G and 102T/C polymorphic regions can be associated with the phenotype or the pathogenesis of panic disorder. 18436425 2008
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 GeneticVariation disease LHGDN This result suggests that 5HTR2A 1438A/G and 102T/C polymorphic regions can be associated with the phenotype or the pathogenesis of panic disorder. 18436425 2008
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 GeneticVariation disease BEFREE Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic association studies in PD. 18832011 2008
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 Biomarker disease BEFREE Here we report the results from an association candidate-gene approach, where we analyzed 15 single nucleotide polymorphisms (SNPs) within the gene coding for the serotonin-receptor 2A (HTR2A) in patients suffering from PD and a control sample. 17440930 2007
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 GeneticVariation disease BEFREE Haplotype analysis supported an association of the cholecystokinin gene TG haplotype with the PD-all group (P = 0.04), whereas DRD1 receptor CAA and HTR2A receptor AT haplotypes were associated with a lower risk for PD-pure phenotype (P = 0.03 and P = 0.04, respectively). 15722953 2005
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 GeneticVariation disease BEFREE No significant transmission disequilibrium was observed between the alleles of the T102C 5-HT2A receptor gene polymorphism and panic disorder, nor was a significant excess of either allele found in the case control analysis. 15182959 2004
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 Biomarker disease BEFREE The study showed a positive association between panic disorder and the HTR2A gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder. 12759158 2003
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 Biomarker disease LHGDN The study showed a positive association between panic disorder and the HTR2A gene, suggesting that HTR2A plays an important role in the pathogenesis of panic disorder. 12759158 2003
CUI: C0030319
Disease: Panic Disorder
Panic Disorder
0.100 GeneticVariation disease BEFREE The authors tested for association of the 5-HT2A receptor polymorphism (T102C) and the intron 7 tryptophan hydroxylase (TPH) polymorphism (A218C) among 176 alcohol dependent patients, 35 patients with panic disorder, 50 patients with generalized anxiety disorder, 55 patients with narcolepsy and 87 healthy controls.3. 11444684 2001