HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 211; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE Previous findings demonstrated that the Gq/11-coupled serotonin 5-HT2A receptor and the Gi/o-coupled metabotropic glutamate 2 (mGlu2) receptor-GPCRs that are involved in signaling alterations associated with psychosis-assemble into a heteromeric complex in the mammalian brain. 26758213 2016
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE While the hypo-activity of serotonin signaling is involved in the pathogenesis of depression, anxiety and obsessive compulsive disorder; LSD, an agonist of serotonin type 2 receptor (5-HTR2A) induces psychosis. 24411530 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 AlteredExpression group BEFREE Disruption of heteromeric expression with mGlu2 attenuates the psychosis-like effects induced in mice by hallucinogenic 5-HT(2A) agonists. 23129762 2013
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. 21550210 2011
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE The strong and robust positive association that was noted between the C allele of HTR2A and psychosis suggests that the HTR2A T102C polymorphism is a significant risk factor for psychosis of AD. 19910872 2010
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: analysis of suicidality in major psychosis. 18783799 2009
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism. 17525976 2008
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis. 18297054 2008
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE Parent-of-origin effect and genomic imprinting of the HTR2A receptor gene T102C polymorphism in psychosis. 17407792 2007
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE No association between the 5-HT2A C102T polymorphism and suicidal behavior in major psychoses was detected with the transmission/disequilibrium test (TDT). 17221840 2007
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE No significant differences in the distribution of allele and genotype frequencies of the 5-HTTLPR (p>0.01) and 5-HT2A T102C (p>0.05) were found between patients and controls as well as between the patients' subgroups without and with psychosis. 17614196 2007
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030 2005
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE No clear association was found between 5-HT2A variants and psychosis. 15048655 2004
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 GeneticVariation group BEFREE Serotoninergic polymorphisms (5-HTTLPR and 5-HT2A): association studies with psychosis in Alzheimer disease. 15000807 2004
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 AlteredExpression group BEFREE The 5-HT2A receptor polymorphism may contribute to the expression of psychosis and agitation/aggression in patients with Alzheimer disease. 15313842 2004
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.400 Biomarker group BEFREE The serotonin receptor type 2A (5-HT2A) is a primary candidate for involvement in major psychoses. 10686558 2000