HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Disease: Seasonal Affective Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE These results suggest that variations in the 5-HTR2A gene play a significant role in the development of seasonality and especially in winter-type SAD. 20580209 2010
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET These results suggest that variations in the 5-HTR2A gene play a significant role in the development of seasonality and especially in winter-type SAD. 20580209 2010
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET Temperament dimensions did not, however, differ significantly between carriers of different (dominant vs. recessive) alleles for the 5-HT(2A)T102C polymorphism in SAD patients. 16899354 2007
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE The results suggest a possible role for the 5-HT(2A)T102C polymorphism in the development of SAD. 16899354 2007
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET The current study investigated whether variation in HTR2A was associated with symptoms of childhood ADHD in adult women with SAD. 12167522 2002
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE The current study investigated whether variation in HTR2A was associated with symptoms of childhood ADHD in adult women with SAD. 12167522 2002
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE There is evidence that the -1438G/A promoter polymorphism of the 5-HT2A gene plays a role in the development of SAD and eating disorders. 11735319 2001
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET There is evidence that the -1438G/A promoter polymorphism of the 5-HT2A gene plays a role in the development of SAD and eating disorders. 11735319 2001
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE Two genetic variants related to serotonergic transmission, the 5-HTTLPR and the 5-HT(2A)-1438G/A gene promoter polymorphisms, have been found to be associated with SAD. 11244145 2001
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET Two genetic variants related to serotonergic transmission, the 5-HTTLPR and the 5-HT(2A)-1438G/A gene promoter polymorphisms, have been found to be associated with SAD. 11244145 2001
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE In conclusion, we have shown that the -1438G/A 5-HT2A promoter variant is associated with SAD but not with seasonality. 10089016 1999
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 AlteredExpression disease BEFREE Lack of association of Val447 and Tyr452 to SAD is consistent with observations showing normal 5-HT2A receptor Ca2+ response in platelets with this disorder, however, the two 5-HT2A amino acid substitutions may lead to differences in behavioral phenotypes. 8959291 1996