HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 289; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 Biomarker phenotype BEFREE The present findings highlight the role of the 5-HT2A receptor system in executive functions and working memory and suggest that specific 5-HT2A antagonists may be relevant for improving cognitive dysfunctions in psychiatric disorders. 31500679 2019
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 PosttranslationalModification phenotype BEFREE Further analysis is needed to identify intrinsic and extrinsic factors that modulate HTR2A methylation, and the mechanism by which this epigenetic variation influences fetal growth and leads to altered brain development, manifesting in psychiatric disorders. 25043477 2014
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 GeneticVariation phenotype BEFREE However, although polymorphisms of the HTR2A gene have been associated with both obesity and psychiatric disorders, the role of HTR2A gene methylation in these illnesses remains uncertain. 24959950 2014
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 GeneticVariation phenotype BEFREE The incidence of psychiatric disorders has been shown to have a strong genetic component, and we conducted this study to investigate whether the -1438A/G polymorphism of the HTR2A gene was associated with susceptibility to schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). 23404241 2013
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 Biomarker phenotype BEFREE Behavioral observations indicated that unlike the 5-HT(2A) agonist (+/-)-1-(2,5-dimethoxy-4-phenyl)-2-aminopropane, lorcaserin did not induce behavioral changes indicative of functional 5-HT(2A) agonist activity. 18252809 2008
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 GeneticVariation phenotype BEFREE We suggest a wider investigation of the HTR2A gene to better understand its role in psychiatric disorders, preferably complemented with the use of proteomic or metabolomic approaches. 17691947 2007
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 GeneticVariation phenotype BEFREE Differential DNA methylation has been suggested to contribute to differential activity of alleles C and T and thereby to genetic associations between the C/T(102) polymorphism in the 5-HT2A receptor gene (5HT2AR) and psychiatric disorders. 16358338 2006
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 AlteredExpression phenotype BEFREE Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders. 14744462 2004
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.090 Biomarker phenotype BEFREE Fine mapping of the human 5-HTR2a gene to chromosome 13q14 and identification of two highly polymorphic linked markers suitable for association studies in psychiatric disorders. 10464662 1999