|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Increasing number of pregnant women at risk of depression are being treated with selective serotonin reuptake inhibitors (SSRI) that bind to serotonin transporters (SERT), which prevents 5-HT binding and cellular internalization, allowing for accumulation of extracellular 5-HT available to bind to 5-HT(2A) receptor (R).
|
31711155 |
2020 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Depression may be associated with altered serotonergic function in the auditory cortex involving the 5-HT2A receptor and is part of a wider view of the pathophysiology of mood disorders extending beyond psychopathology.
|
31120232 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
They may play a role in depression through an ability of 5-HT2A protomer signaling to inhibit the 5-HT1A protomer recognition and signaling.
|
29865267 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
It is proposed that the demonstrated 5-HT1A-5-HT2A isoreceptor complexes may play a role in depression through integration of 5-HT recognition, signaling and trafficking in the plasma membrane in two major 5-HT receptor subtypes known to be involved in depression.
|
28920103 |
2017 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
It also provided evidence that 5-HTR2A mRNA levels in PBMCs of MDD patients could be associated with the severity of depression and the duration of the illness.
|
28125323 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Previous studies have identified SLC6A4 and HTR2A associations with SSRI response in patients with depression and 5-HTTLPR (SLC6A4) associations with escitalopram response in ASD.
|
26262902 |
2015 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like.
|
25106036 |
2014 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The frontal abnormality of patients with depression had certain 5-HT genetic basis, and 5-HT2A receptor CC allele and MAOA-H genotype had synergistic effect on the activity abnormality when recognizing negative emotion in right frontal middle gyrus of patients with depression.
|
24314147 |
2014 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Associations between suicidal ideation and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, and 5-HTR2a 102T/C genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method after adjustment for potential covariates, including depression.
|
23973249 |
2014 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression.
|
23221997 |
2013 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Targeted analysis of HTR2A in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study reveals associations between functional variants and depression severity or citalopram response.
|
23158458 |
2013 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.
|
23537781 |
2013 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This study aimed to investigate whether polymorphisms of interest in 5-HTT, 5-HTR2a, and BDNF genes are associated with depression after mastectomy for breast cancer.
|
22210241 |
2012 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
SNPs in HTR2A were associated with both pain phenotypes in the discovery cohort, and a number of these SNP associations were replicated in the validation cohort, some of which were attenuated after adjustment for depression.
|
21305503 |
2011 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R).
|
20383137 |
2010 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine.
|
18801406 |
2008 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Alterations in the constitutive activity of 5-HT(2A) and 5-HT(2C) receptor systems could be involved in the mechanisms underlying anxiety and depression or exploited for therapeutic benefit.
|
18772038 |
2008 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Reports have shown an association of a serotonin-2A receptor (HTR2A) gene T102C polymorphism with AD + P and with depression during AD.
|
17525976 |
2007 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The HTR2A gene may be involved in the development of depression by influencing the ability of individuals to use environmental support.
|
17339524 |
2007 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The HTR2A gene may be involved in the development of depression by influencing how individuals respond to environmental conditions.
|
17510953 |
2007 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men.
|
16806099 |
2007 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Altered HTR2A expression has been found in relation to several neuropsychiatric conditions, including depression and schizophrenia.
|
17069769 |
2006 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5-HT2A and serotonin transporter linked polymorphic region -5-HTTLPR- of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.
|
17183148 |
2006 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Upregulation and/or increased sensitivity of 5-HT2A/1B receptors and downregulated 5-HT transporter receptors in the periphery may contribute to increased risk of thromboembolic events in patients with depression and cardiovascular disease.
|
14508013 |
2004 |