|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Our study demonstrated that TNF-α 308 G/A, 5-HTT LPR, and 5-HTT-VNTR polymorphisms were associated with OSAS risk, whereas little association was observed between 5-HTR2A 102C/T, 5-HTR2A A1438G, ACE I/D, or LEPR-Gln 223Arg polymorphism and risk of OSAS in the Chinese population.
|
25917830 |
2015 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
There was no significant association between 5-HT2A 102C/T and OSAS risk, using any model.
|
24755731 |
2014 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The G allele of 5-HTR2A 1438G/A, long 5-HTTLPR, and 10-tandem-repeats STin2VNTR were shown to increase OSAS susceptibility, with ORs of 2.33 (A vs. G, 95% CI 1.48-3.66), 1.24 (L vs. S, 95% CI: 1.04-1.49), and 2.87 (10 vs. 12, 95% CI: 1.38-5.97), respectively.
|
24475124 |
2014 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the prevalence of the 102T-C and -1438G-A polymorphisms in the 5-HTR2A gene in Brazilian patients with and without OSAS.
|
22281949 |
2013 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Association between 5-HT2A receptor polymorphisms and risk of obstructive sleep apnea and hypopnea syndrome: a systematic review and meta-analysis.
|
23988500 |
2013 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
For the T102C genotype, no significantly increased OSA risk was associated with the two variant genotypes (CC vs. CT+TT: OR 1.065, 95 % CI 0.787-1.442, P = 0.361 for heterogeneity; C allele carriers vs. TT: OR 0.979, 95 % CI 0.737-1.3, P = 0.9 for heterogeneity).In conclusions, meta-analysis indicated that the -1438G/A, and not T102C, polymorphism of 5-HT2A is a positive risk factor of OSA, especially in males.
|
24065538 |
2013 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to assess the association of polymorphisms in all exons and promoter region of the 5-HT2A receptor gene with OSAHS in a Chinese Han population.
|
22074567 |
2012 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To investigate the prevalence of T102C and -1438G/A polymorphisms in the 5-HTR2A gene of patients with and without OSAS.
|
21739010 |
2011 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In African Americans, rs9526240 within serotonin receptor 2a (HTR2A: odds ratio = 2.1; 95% confidence interval, 1.5-2.9; P = 0.00005233) was associated with OSA.
|
20538960 |
2010 |