HTR2A, 5-hydroxytryptamine receptor 2A, 3356

N. diseases: 211; N. variants: 20
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker disease BEFREE When patients were subdivided according to the presence or absence of psychotic symptoms, we confirmed the association between cocaine dependence and HTR2A in both subgroups of patients. 23241418 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker disease CTD_human Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. 19212317 2009
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker disease CTD_human Relationship of cocaine-induced c-Fos expression to behaviors and the role of serotonin 5-HT2A receptors in cocaine-induced c-Fos expression. 16300424 2006
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker disease CTD_human These results suggest that 5-HT2A receptors play an important role in the behavioral effects of cocaine and that 5-HT2A receptors should be considered a viable target for analysis in the search for pharmacotherapies useful in the treatment of cocaine dependence. 11259563 2001
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker disease CTD_human Serotonin (5-hydroxytryptamine; 5-HT) 5-HT(2A) receptors have been shown to modulate dopamine (DA) function and a more thorough appreciation of this modulatory interaction between 5-HT2A receptors and DA systems may yield insight into novel approaches to treatment of cocaine dependence. 11259563 2001