HTR2B, 5-hydroxytryptamine receptor 2B, 3357

N. diseases: 61; N. variants: 4
Disease: Heart valve disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018824
Disease: Heart valve disease
Heart valve disease 		0.500 Therapeutic group RGD Therefore, we sought to determine whether cyproheptadine, a 5-HT(2B)R antagonist, might prevent toxic valvulopathy in an animal model of pergolide-induced valvular heart disease. 19346455 2009
CUI: C0018824
Disease: Heart valve disease
Heart valve disease 		0.500 Biomarker group CTD_human A more likely cause of fenfluramine-induced valvulopathy is activation of 5-HT(2B) receptors on heart valves by the metabolite norfenfluramine. 19505264 2009
CUI: C0018824
Disease: Heart valve disease
Heart valve disease 		0.500 Biomarker group CTD_human [Pergolide associated valvulopathy: critical analysis of the literature and practical recommendations]. 16141947 2005
CUI: C0018824
Disease: Heart valve disease
Heart valve disease 		0.500 Biomarker group CTD_human Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine. 10617681 2000
CUI: C0018824
Disease: Heart valve disease
Heart valve disease 		0.500 Biomarker group CTD_human Our data imply that activation of 5-HT(2B) receptors is necessary to produce VHD and that serotonergic medications that do not activate 5-HT(2B) receptors are unlikely to produce VHD. 11104741 2000