HTR2C, 5-hydroxytryptamine receptor 2C, 3358

N. diseases: 140; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 GeneticVariation disease BEFREE We aim to investigate whether the -759C÷T polymorphism in 5-HTR2C gene was associated with weight change and hyperinsulinemia in Romanian pediatric patients with schizophrenia and bipolar disorders. 28174802 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease BEFREE We recently found greater 5-HT(2C)R editing in suicide victims with prior bipolar disorder (BPD) or schizophrenia (SZ) compared with non-suicide patients and normal controls (NC). 22404657 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease PSYGENET We recently found greater 5-HT(2C)R editing in suicide victims with prior bipolar disorder (BPD) or schizophrenia (SZ) compared with non-suicide patients and normal controls (NC). 22404657 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease PSYGENET Serotonin receptor 2C (HTR2C) has been postulated as being involved in the etiology or pathophysiology of mental disorders such as bipolar disorder, major depression and schizophrenia. 20015120 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease BEFREE Serotonin receptor 2C (HTR2C) has been postulated as being involved in the etiology or pathophysiology of mental disorders such as bipolar disorder, major depression and schizophrenia. 20015120 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease PSYGENET Further evidence supporting the association between 5HTR2C gene and bipolar disorder. 20494452 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease BEFREE Further evidence supporting the association between 5HTR2C gene and bipolar disorder. 20494452 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease PSYGENET Here we overviewed the genetic, expression and RNA editing studies suggesting the close relationship between HTR2C and major mental disorders including schizophrenia, bipolar disorder and major depression. 19411841 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease PSYGENET Furthermore, we performed a particular gene-gene interaction for the X-linked serotonergic genes (HTR2C and MAOA), and found no association among this intergenic haplotype combination and suicidal behaviour in bipolar disorder. 18504633 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 GeneticVariation disease BEFREE These results indicate that the HTR2C promoter polymorphism does not contribute significantly to the etiopathogenesis of bipolar disorder in females. 12111480 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 GeneticVariation disease BEFREE Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder. 11502363 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 GeneticVariation disease BEFREE We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. 9342201 1997
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.380 Biomarker disease BEFREE Overall, there was no significant difference in allele frequencies between the two groups, indicating that the 5-HT2C gene is not a major risk factor for bipolar affective disorder. 8823764 1996