|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The serotonin receptor 2C (5HT2C) is an important drug target to treat obesity and depression.
|
29969651 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The development of drugs that specifically target 5-HT2C receptors will allow for better understanding of their involvement in the pathophysiology of psychiatric disorders including schizophrenia, anxiety, and depression.
|
26739950 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The melatonin MT1/MT2 agonist and 5-HT(2C) antagonist, agomelatine, which is effective in the short- and long-term treatment of depression, exemplifies the former approach, while evidence-based polypharmacy is illustrated by the adjunctive use of second-generation antipsychotics with serotonin reuptake inhibitors for treatment of resistant depression.
|
23719026 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activity of the x-linked serotonin 5-HTR2C receptor has also been shown to be associated with depression and with clinical response to antidepressant medications.
|
25514629 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association of 5-HTR2A and 5-HTR2C serotonin receptor gene polymorphisms with depression risk in patients with coronary heart disease.
|
24770757 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The melatonin MT1/MT2 agonist and 5-HT(2C) antagonist, agomelatine, which is effective in the short- and long-term treatment of depression, exemplifies the former approach, while evidence-based polypharmacy is illustrated by the adjunctive use of second-generation antipsychotics with serotonin reuptake inhibitors for treatment of resistant depression.
|
23719026 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, 5-HT2CR signaling enhancement and the subsequent activation of the CRF neuron were involved in novelty-induced hypophagia in aged mice, and the 5-HT2CR antagonists offer a promising therapeutic option for depression.
|
23583320 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In conclusion, 5-HT2CR signaling enhancement and the subsequent activation of the CRF neuron were involved in novelty-induced hypophagia in aged mice, and the 5-HT2CR antagonists offer a promising therapeutic option for depression.
|
23583320 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
These findings suggest that activation of 5-HT(2C)R in discrete brain regions contributes to specific anxiety- and depression-like behaviors and may indicate potential brain sites involved in the anxiolytic and antidepressant effects of exercise.
|
23049953 |
2012 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
These data constitute the first in vivo demonstration of a role for 5-HT(2C)R mRNA editing in anxiety- and depression-related behaviors.
|
20624407 |
2010 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The new antidepressant agomelatine is the first melatonergic antidepressant with an innovative mode of action: it is a melatonergic MT(1), MT(2) receptor agonist and 5-HT(2c) antagonist, and is able to restore the internal clock, which is profoundly disturbed in depression, thus being efficacious in major depressive disorders.
|
19708722 |
2009 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alterations in the constitutive activity of 5-HT(2A) and 5-HT(2C) receptor systems could be involved in the mechanisms underlying anxiety and depression or exploited for therapeutic benefit.
|
18772038 |
2008 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present review, the pathopharmacological significance of 5-HT2CR in special reference to RNA editing of receptors is reviewed and discussed from the aspect of development of novel therapeutics for depression.
|
16799258 |
2006 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Based on the literature, we hypothesized that the 5-HT2A and 5-HT2C receptor polymorphisms would be associated with agitation/aggression and psychosis and the 5-HTTPR or 5-HTTVNTR polymorphisms, with agitation/aggression or depression and anxiety.
|
15313842 |
2004 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results support the hypothesis that 5-HT(2C)R mRNA editing has causative relevance in the pathophysiology of depression associated with cytokine therapy.
|
15093687 |
2004 |