HTR2C, 5-hydroxytryptamine receptor 2C, 3358

N. diseases: 140; N. variants: 11
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE Therefore, HTR2C genetic variants may be involved in the susceptibility to MS in patients treated with atypical antipsychotics. 29441581 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE An association has been found between the C allele of the rs1414334 polymorphism in the HTR2C gene and the metabolic syndrome in psychiatric patients. 28492956 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE We found associations with outcomes such as increases in BMI and metabolic syndrome for variants in genes such as LEP and HTR2C. 28879574 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease BEFREE This study confirms a high prevalence of metabolic side effects with clozapine and suggests higher clozapine level and pharmacogenetic markers in CYP2C19, LEP, LEPR, and HTR2C receptors as important predictors of BMI and metabolic syndrome. 27681143 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE Several genes showed strong evidence for an association with MetS in patients with schizophrenia, including the fat mass and obesity associated gene (FTO), leptin and leptin receptor genes (LEP, LEPR), methylenetetrahydrofolate reductase (MTHFR) gene and the serotonin receptor 2C gene (HTR2C). 26621002 2016
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE A pharmacogenomic analysis revealed the presence of the 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C) -759C genotype which is related to increased risk for metabolic syndrome. 26359410 2016
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE HTR2C polymorphisms, olanzapine-induced weight gain and antipsychotic-induced metabolic syndrome in schizophrenia patients: a meta-analysis. 25152019 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE No association was found between the HTR2C -759 C/T polymorphism and the metabolic syndrome. 20680028 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE Association between HTR2C polymorphisms and metabolic syndrome in patients with schizophrenia treated with atypical antipsychotics. 21185157 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease CTD_human The variants of HTR2C:c.1-142948(GT)n (odds ratio [OR], 1.69; 95% confidence interval [CI], 0.75-3.81) and rs1414334 (OR, 2.35; 95% CI, 0.96-5.77) were not significantly associated with the metabolic syndrome in the replication sample but did show significance in the pooled analysis (OR, 2.09; 95% CI, 1.12-3.91; and OR, 2.35; 95% CI, 1.19-4.62, respectively). 19142101 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE The variants of HTR2C:c.1-142948(GT)n (odds ratio [OR], 1.69; 95% confidence interval [CI], 0.75-3.81) and rs1414334 (OR, 2.35; 95% CI, 0.96-5.77) were not significantly associated with the metabolic syndrome in the replication sample but did show significance in the pooled analysis (OR, 2.09; 95% CI, 1.12-3.91; and OR, 2.35; 95% CI, 1.19-4.62, respectively). 19142101 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease CTD_human Patients (n=134) were assessed for measures of obesity, other factors contributing to metabolic syndrome, and two genetic polymorphisms (5-HT(2C) receptor -759C/T and leptin -2548A/G). 18515891 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 GeneticVariation disease BEFREE Carriership of the variant alleles of the HTR2C polymorphisms rs518147, rs1414334, and HTR2C:c.1-142948(GT)n was associated with an increased risk of the metabolic syndrome (adjusted odds ratio [OR], 2.62 [95% confidence interval {CI}, 1.00-6.85]; OR, 4.09 [95% CI, 1.41-11.89]; and OR, 3.12 [95% CI, 1.13-8.16]), respectively. 17632216 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.400 Biomarker disease CTD_human Carriership of the variant alleles of the HTR2C polymorphisms rs518147, rs1414334, and HTR2C:c.1-142948(GT)n was associated with an increased risk of the metabolic syndrome (adjusted odds ratio [OR], 2.62 [95% confidence interval {CI}, 1.00-6.85]; OR, 4.09 [95% CI, 1.41-11.89]; and OR, 3.12 [95% CI, 1.13-8.16]), respectively. 17632216 2007