Mood Disorders
|
0.350 |
Biomarker
|
group |
PSYGENET |
The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial.
|
25596490 |
2015 |
Mood Disorders
|
0.350 |
GeneticVariation
|
group |
BEFREE |
The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial.
|
25596490 |
2015 |
Mood Disorders
|
0.350 |
GeneticVariation
|
group |
BEFREE |
In humans, a common missense single-nucleotide change (rs6318, rs6318" genes_norm="3358">Cys23Ser) in the 5-HT(2C) receptor gene (HTR2C) has been associated with altered activity in vitro and with clinical mood disorders.
|
22764241 |
2012 |
Mood Disorders
|
0.350 |
Biomarker
|
group |
PSYGENET |
In humans, a common missense single-nucleotide change (rs6318, Cys23Ser) in the 5-HT(2C) receptor gene (HTR2C) has been associated with altered activity in vitro and with clinical mood disorders.
|
22764241 |
2012 |
Mood Disorders
|
0.350 |
Biomarker
|
group |
PSYGENET |
Glucocorticoid receptor-impaired (GR-i) mice, a transgenic model for affective disorders with hypothalamic-pituitary-adrenal (HPA) axis feedback control deficit, were used to assess the antidepressant-like effects of the mixed melatonin receptor agonist/5-HT(2C) receptor antagonist, agomelatine, compared to the selective 5-HT reuptake inhibitor (SSRI), fluoxetine, on hippocampal neurogenesis, GR and BDNF expression and antidepressant-responsive behaviour (tail suspension test, TST).
|
19775499 |
2010 |
Mood Disorders
|
0.350 |
Biomarker
|
group |
PSYGENET |
In order to test the hypothesis that increased 5-HT(2C) receptor expression, and thus increased 5-HT(2C) receptor signalling, is causative in mood disorders, we have undertaken a transgenic approach, directly altering the 5-HT(2C) receptor number in the forebrain and evaluating the consequences on behaviour.
|
19614978 |
2009 |
Mood Disorders
|
0.350 |
GeneticVariation
|
group |
BEFREE |
Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients.
|
18715570 |
2009 |
Mood Disorders
|
0.350 |
Biomarker
|
group |
PSYGENET |
Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients.
|
18715570 |
2009 |
Mood Disorders
|
0.350 |
Biomarker
|
group |
BEFREE |
The 5-HT2C receptor as a target for mood disorders.
|
14996615 |
2004 |
Mood Disorders
|
0.350 |
GeneticVariation
|
group |
BEFREE |
We examined a structural variant of the serotonin 2C (5-HT2C) receptor gene (HTR2C) that gives rise to a cysteine to serine substitution in the N terminal extracellular domain of the receptor protein (cys23ser),(5) in 513 patients with recurrent major depression (MDD-R), 649 patients with bipolar (BP) affective disorder and 901 normal controls.
|
11526472 |
2001 |