Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tenascin-C is an extracellular matrix protein known to correlate with prognosis in patients with glioblastoma, probably by stimulation of invasion and neoangiogenesis.
|
16292494 |
2006 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that endogenous tenascin-C contributes the invasive nature of glioblastoma and the compositional change of brain tissue, which renders tenascin-C as a prime candidate for anti-invasion therapy for glioblastoma.
|
19459858 |
2009 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tenascin-C (TNC) expression is known to correlate with malignancy in glioblastoma (GBM), a highly invasive and aggressive brain tumor that shows limited response to conventional therapies.
|
19147558 |
2009 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine if a reduction in the expression level of caveolin-1 mRNA and protein accompanied the transformation of astrocytes, we undertook studies of two transformed rat astroglial cell lines, C6 and DI TNC(1), as well as several cell lines derived from human glioblastoma tumors: T98G, U87MG, U118MG, U138MG, and U373MG.
|
11857686 |
2002 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrate the proximal localization of TNC and BTIC in human glioblastoma specimens and in orthotopic murine xenografts of human BTIC implanted intracranially.
|
28416488 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, tenascin-C (TN-C) as a dominant epitope in glioblastoma has been discovered.
|
16775434 |
2006 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression.
|
20622113 |
2010 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Robust expression of TN-C was found within the tumor mass of surgery specimens from glioblastoma.
|
23963648 |
2013 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The specific effect of ATN-RNA on TN-C downregulation was proved with antibodies against TN-C in glioblastoma multiforme cultured cells.
|
20118657 |
2010 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report new approach towards RNA interference therapy of glioblastoma multiforme based on the magnetic nanoparticles delivery of the double-stranded RNA (dsRNA) with homological sequences to mRNA of tenascin-C (TN-C), named ATN-RNA.
|
30889203 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To identify an aptamer for testing as a tumor-selective ligand, SELEX (systematic evolution of ligands by exponential enrichment) procedures were performed using both TN-C and TN-C-expressing U251 glioblastoma cells.
|
11590140 |
2001 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The latter is a DNA aptamer that can recognize the extracellular matrix protein tenascin-C on the surface of human glioblastoma cells.
|
24432373 |
2013 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, the tenascin-C/TNIIIA2 could be a potential therapeutic target for glioblastoma.
|
31261783 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Distribution pattern of tenascin-C in glioblastoma: correlation with angiogenesis and tumor cell proliferation.
|
16388320 |
2005 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we demonstrate dual activities for tenascin-C in glioblastoma angiogenesis and uncover potential targeting and prediction opportunities.
|
27926865 |
2016 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of the tenascin-C/β1-integrin axis may be a therapeutic target for glioblastoma, and peptide FNIII14 may represent a new approach for glioblastoma chemotherapy.
|
31189613 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Distribution pattern of tenascin-C in glioblastoma: correlation with angiogenesis and tumor cell proliferation.
|
16388320 |
2005 |