Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
GeneticVariation
|
disease |
BEFREE |
The most frequent monogenic causes of low plasma cholesterol are familial hypobetalipoproteinemia (FHBL1) because of truncating mutations in apolipoprotein B coding gene (APOB) and familial combined hypolipidemia (FHBL2) due to loss-of-function mutations in ANGPTL3 gene.
|
28733173 |
2018 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Novel APOB missense variants, A224T and V925L, in a black South African woman with marked hypocholesterolemia.
|
27206948 |
2017 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Genetic diagnosis of familial hypercholesterolemia in Han Chinese.
|
27206935 |
2017 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes.
|
27604308 |
2016 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Refinement of variant selection for the LDL cholesterol genetic risk score in the diagnosis of the polygenic form of clinical familial hypercholesterolemia and replication in samples from 6 countries.
|
25414277 |
2015 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL-C levels in a latvian population.
|
26415676 |
2015 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Novel functional APOB mutations outside LDL-binding region causing familial hypercholesterolaemia.
|
24234650 |
2014 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.
|
24507775 |
2014 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Quality assessment of the genetic test for familial hypercholesterolemia in the Netherlands.
|
23936638 |
2013 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Spectrum of mutations and phenotypic expression in patients with autosomal dominant hypercholesterolemia identified in Italy.
|
23375686 |
2013 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Familial hypobetalipoproteinemia-induced nonalcoholic steatohepatitis.
|
22855658 |
2012 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Microfluidic amplification as a tool for massive parallel sequencing of the familial hypercholesterolemia genes.
|
22294733 |
2012 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels.
|
22095935 |
2012 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
A novel mutation of apolipoprotein B in a French Canadian family with homozygous hypobetalipoproteinemia.
|
21981844 |
2012 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Reduced penetrance of autosomal dominant hypercholesterolemia in a high percentage of families: importance of genetic testing in the entire family.
|
21868016 |
2011 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Array-based resequencing for mutations causing familial hypercholesterolemia.
|
21376320 |
2011 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.
|
21059979 |
2010 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
GeneticVariation
|
disease |
CLINVAR |
Nonsynonymous mutations within APOB in human familial hypobetalipoproteinemia: evidence for feedback inhibition of lipogenesis and postendoplasmic reticulum degradation of apolipoprotein B.
|
20032471 |
2010 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
High-resolution melting analysis for detection of familial ligand-defective apolipoprotein B-100 mutations.
|
18325181 |
2008 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Detection of familial defective apoB (FDB) mutations in hypercholesterolemic children and adolescents by denaturing high performance liquid chromatography (DHPLC).
|
18222178 |
2008 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Molecular diagnosis of hypobetalipoproteinemia: an ENID review.
|
17570373 |
2007 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Update of the molecular basis of familial hypercholesterolemia in The Netherlands.
|
16250003 |
2005 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Mutation in apolipoprotein B associated with hypobetalipoproteinemia despite decreased binding to the low density lipoprotein receptor.
|
15797858 |
2005 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
A novel nontruncating APOB gene mutation, R463W, causes familial hypobetalipoproteinemia.
|
12551903 |
2003 |
Acanthocytosis With Hypobetalipoproteinemia
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Compound heterozygous familial hypercholesterolemia and familial defective apolipoprotein B-100 produce exaggerated hypercholesterolemia.
|
11238294 |
2001 |