Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Differently, the correlation between sICAM-1 and sVCAM-1 was observed only in MS patients. sNCAM and sVCAM-1 levels were higher in P-MS compared to HI (P = 0.05 and P = 0.028 respectively).
|
30412901 |
2019 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic effect of the <i>ICAM1</i> (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis.
|
30473535 |
2018 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our analysis revealed no statistically significant association of ICAM1 polymorphisms with risk of MS development in the Slovak population.
|
28130760 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that the ICAM-1 isoform lacking Ig domain 4 can drive pathogenesis in demyelinating disease and may be a novel therapeutic target for treating multiple sclerosis.
|
24435747 |
2014 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Soluble forms of vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and E-Selectin play a role in the regulation of blood-brain barrier damage and represent markers of the clinical course of multiple sclerosis (MS) and magnetic resonance imaging activity.
|
20175758 |
2010 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We concluded that role of the ICAM-1 gene polymorphisms in the pathogenesis of multiple sclerosis is still controversial and should be studied further.
|
17868277 |
2007 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Intercellular adhesion molecule-1 gene polymorphism in Iranian patients with multiple sclerosis.
|
17868277 |
2007 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
We observed a rare, and an as yet unreported, ICAM-1 gene haplotype defined by amino acids K469 and R241 that was never transmitted to patients suggesting a protective effect against MS in our population.
|
14551606 |
2003 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).
|
12590979 |
2003 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Differential regulation of membrane bound and soluble ICAM 1 in human endothelium and blood mononuclear cells: effects of interferon beta-1a.
|
12745437 |
2003 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We observed a rare, and an as yet unreported, ICAM-1 gene haplotype defined by amino acids K469 and R241 that was never transmitted to patients suggesting a protective effect against MS in our population.
|
14551606 |
2003 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Effect of IFNbeta-1a over expression of the ICAM 1 isoforms might have a relevant immunomoregulatory role in Multiple Sclerosis.
|
12745437 |
2003 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
ICAM-1 gene is not associated with multiple sclerosis in sardinian patients.
|
11081805 |
2000 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease.
|
10792421 |
2000 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To detect ICAM-1 gene polymorphisms in MS, we have developed a highly sensitive and site-specific, two-stage, nested polymerase chain reaction.
|
9667594 |
1998 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study investigates the expression of T cell receptor V delta 1 chain, interleukin-2 receptor alpha-chain (CD25) and adhesion molecules ICAM-1 (CD54), LFA-1 (CD11a/18) and CD44 on gamma delta+ T cells by three-color flow cytometry on cerebrospinal fluid (CSF) and blood cells in patients with multiple sclerosis (MS), other inflammatory neurological diseases (OIND) and other neurological diseases (OND).
|
7507498 |
1994 |