Congenital ocular coloboma (disorder)
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Panel-based whole exome sequencing identifies novel mutations in microphthalmia and anophthalmia patients showing complex Mendelian inheritance patterns.
|
29178648 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study.
|
27212621 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
As such, GPR120 is a potential target of pharmaceuticals for type II diabetes.
|
29373685 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus.
|
23317787 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although there is great interest in the potential of free fatty acid receptor 4 (FFA4) as a novel therapeutic target for the treatment of type II diabetes, the broad distribution pattern of this receptor suggests it may play a range of roles beyond glucose homeostasis in different cells and tissues.
|
28385906 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GPR120, which is activated by long-chain free fatty acids (FFAs), has been recognized as a new attractive target for the treatment of type 2 diabetes and metabolic disease.
|
28435531 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
GPR120 is an attractive target for the treatment of type 2 diabetes.
|
29980358 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extensive SAR studies of a series of phenylpropanoic acids led to the identification of compound 29, a FFA4 agonist which lowers plasma glucose in two preclinical models of type 2 diabetes.
|
28148462 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
One lead compound is a potent GPR120 agonist, has good selectivity for related receptor GPR40 (FFAR1), has acceptable PK properties, and is active in 2 models of Type 2 Diabetes in mice.
|
29456108 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study does not exclude that other coding mutations in FFAR4 with stronger functional effect than p.R270H may be associated with T2D.
|
26025001 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.
|
28947942 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
G-protein coupled receptor 120 (GPR120) has recently emerged as a potential therapeutic target for treating T2DM.
|
28105274 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
GPR120 is a novel target for the treatment of metabolic disease and type 2 diabetes.
|
31691553 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
Free Fatty Acid receptor 4 (FFA4), also known as GPR120, is a G-protein-coupled receptor (GPCR) responsive to long-chain fatty acids that is attracting considerable attention as a potential novel therapeutic target for the treatment of type 2 diabetes mellitus (T2DM).
|
28734639 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes.
|
28105282 |
2017 |
Microphthalmos
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Panel-based whole exome sequencing identifies novel mutations in microphthalmia and anophthalmia patients showing complex Mendelian inheritance patterns.
|
29178648 |
2017 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data suggest that activation of brown adipocytes with the GPR120 agonist TUG-891 is a promising strategy to increase lipid combustion and reduce obesity.
|
29343498 |
2018 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states.
|
27980130 |
2017 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that GPR120-deficient mice fed a high-fat diet develop obesity, glucose intolerance and fatty liver with decreased adipocyte differentiation and lipogenesis and enhanced hepatic lipogenesis.
|
22343897 |
2012 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated with altered duodenal expression of FFAR1, FFAR4 and CD36, suggesting altered capacity for the sensing, absorption and metabolism, of dietary lipids.
|
27811952 |
2017 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the effects of GPR120 activation on dietary fat intake or obesity are not clearly understood.
|
31806728 |
2020 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, GPR120 KO mice develop obesity, increased inflammation, and insulin resistance, consistent with a role for GPR120 signaling in the metabolic syndrome and diabetes mellitus.
|
22560206 |
2012 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effects of FAs on TNF-α, IL-6, IL-10 and adiponectin expression in non-obese and MO subjects were significantly annulled when the GPR120 gene was silenced in visceral adipocytes differentiated from human mesenchymal stem cells.
|
27299582 |
2017 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we evaluate the expression and potential role of hypothalamic GPR120 and GPR40 as targets for the treatment of obesity.
|
28446241 |
2017 |
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In humans, the loss of function p.R270H variant of the gene FFAR4 has been associated with a lower protein activity, an increased risk of obesity and higher fasting plasma glucose levels.
|
27212621 |
2016 |