|
Metabolic Syndrome X
|
0.030 |
Biomarker
|
disease |
BEFREE |
In addition, GPR120 KO mice develop obesity, increased inflammation, and insulin resistance, consistent with a role for GPR120 signaling in the metabolic syndrome and diabetes mellitus.
|
22560206 |
2012 |
|
Metabolic Syndrome X
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings suggest that redox regulation of GPR120/FFAR4 might be an important target in reducing risk of metabolic syndrome and associated diseases.
|
30658097 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The upregulation FFAR4 expression was associated with the lymph node metastasis and the prognosis.
|
31539131 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the degree of FFAR4 expression was associated with aggressive clinicopathological characteristics, such as histological grade, perineural invasion (PNI), lymph node metastasis (LNM), advanced TNM stage and preoperative serum CA19-9 level (P< 0.05).
|
30248044 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression of GPR120 was significantly related with histological grade, TNM stage and lymph node metastasis.
|
29901155 |
2018 |
|
Steatohepatitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).
|
29126901 |
2018 |
|
Steatohepatitis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
After DHA treatment, the following modifications were present: i) the improvement of histo-pathological parameters such as NAFLD activity score, ballooning, and steatosis; ii) the reduction of hepatic progenitor cell activation in correlation with histo-pathological parameters; iii) the reduction of the number of inflammatory macrophages; iv) the increase of GPR120 expression in hepatocytes; v) the reduction of serine-311-phosphorylated nuclear factor kappa B (NF-κB) nuclear translocation in hepatocytes and macrophages in correlation with serum inflammatory cytokines.
|
24505350 |
2014 |
|
Steatohepatitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here we show that GPR120-deficient mice fed a high-fat diet develop obesity, glucose intolerance and fatty liver with decreased adipocyte differentiation and lipogenesis and enhanced hepatic lipogenesis.
|
22343897 |
2012 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prolonged administration of GW9508 resulted in significant amelioration of atherogenesis, providing evidence that the strategy based on macrophage phenotype switching toward an M2-like activation state via stimulation of FFAR1/FFAR4 receptors holds promise for a new approach to the prevention or treatment of atherosclerosis.
|
31129318 |
2019 |
|
Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.
|
27811230 |
2017 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prolonged administration of GW9508 resulted in significant amelioration of atherogenesis, providing evidence that the strategy based on macrophage phenotype switching toward an M2-like activation state via stimulation of FFAR1/FFAR4 receptors holds promise for a new approach to the prevention or treatment of atherosclerosis.
|
31129318 |
2019 |
|
Atherosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice.
|
27811230 |
2017 |
|
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GPR120 expression and tumor thickness (mm) show a statistically significant correlation in primary melanoma (P=0.011).
|
29570170 |
2018 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells.
|
27163640 |
2016 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overall, these findings define a mechanism by which FFAR1-and FFAR4-dependent activation of Hippo pathway mediates DHA-induced apoptosis of androgen-independent prostate cancer cells, thus providing a promising therapeutic target for prostate cancer.
|
30366669 |
2018 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In human tissue, higher expression of stromal GPR120 correlated with greater reduction in expression of CCP genes in men with prostate cancer on a high-ω-3 diet (r = -.57, P = .04).
|
30202902 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
After DHA treatment, the following modifications were present: i) the improvement of histo-pathological parameters such as NAFLD activity score, ballooning, and steatosis; ii) the reduction of hepatic progenitor cell activation in correlation with histo-pathological parameters; iii) the reduction of the number of inflammatory macrophages; iv) the increase of GPR120 expression in hepatocytes; v) the reduction of serine-311-phosphorylated nuclear factor kappa B (NF-κB) nuclear translocation in hepatocytes and macrophages in correlation with serum inflammatory cytokines.
|
24505350 |
2014 |
|
Non-alcoholic Fatty Liver Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We examined the association between NAFLD and eleven single nucleotide polymorphisms (SNPs) at genetic loci potentially associated with liver damage (GCKR, MBOAT7, GPR120), oxidative stress (SOD2), lipid metabolism (PNPLA3, TM6SF2, LPIN1, ELOVL2, FADS2, MTTP) and fibrogenesis (KLF6) in a paediatric population.
|
31255630 |
2019 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overall, these findings define a mechanism by which FFAR1-and FFAR4-dependent activation of Hippo pathway mediates DHA-induced apoptosis of androgen-independent prostate cancer cells, thus providing a promising therapeutic target for prostate cancer.
|
30366669 |
2018 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In human tissue, higher expression of stromal GPR120 correlated with greater reduction in expression of CCP genes in men with prostate cancer on a high-ω-3 diet (r = -.57, P = .04).
|
30202902 |
2019 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice.
|
28039475 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, we find that GPR120 expression is positively correlated with VEGF expression and inversely correlated with the epithelial marker E-cadherin in CRC tissues.
|
23851494 |
2013 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was aimed at figuring out whether DHA could ameliorate the Crohn's colitis by activating GPR120 and whether GPR120 could be a potential therapeutic target for CD.16 week-old mice included in our present study were divided into three groups, WT group, IL-10 KO group and DHA group(IL-10 KO mice with DHA treatment, i.g., 35.5mg/kg/d), containing 8 mice in each group.
|
28039475 |
2017 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we show that GPR120-deficient mice fed a high-fat diet develop obesity, glucose intolerance and fatty liver with decreased adipocyte differentiation and lipogenesis and enhanced hepatic lipogenesis.
|
22343897 |
2012 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
ω3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4.
|
27986444 |
2017 |