Anemia, Sickle Cell
|
0.020 |
Biomarker
|
disease |
BEFREE |
Valsartan impedes epinephrine-induced ICAM-4 activation on normal, sickle cell trait and sickle cell disease red blood cells.
|
31083675 |
2019 |
Anemia, Sickle Cell
|
0.020 |
Biomarker
|
disease |
BEFREE |
Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs via AKAPs Is Revealed by AFM.
|
28076805 |
2017 |
Hematological Disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition, two new subphenotype-specific associations have been detected: SNP rs5754217 (UBE2L3) with skin involvement and rs3093030 (ICAM1-ICAM4-ICAM5) with hematological disorders.
|
27021335 |
2016 |
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicate that ICAM-1 and ICAM-4 play roles in host cell invasion by M. tuberculosis and P. falciparum, respectively, either as receptors or as crucial accessory molecules.
|
25586702 |
2015 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
ICAM-4 binds to P. falciparum merozoites, and the addition of recombinant ICAM-4 to parasite cultures blocks invasion of erythrocytes by newly released merozoites.
|
25586702 |
2015 |
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The A-allele of ICAM1-ICAM4-ICAM5 rs3093030, associated with elevated plasma levels of soluble ICAM1, and the A-allele of ITGAM rs1143679 showed the strongest association with increased SLE susceptibility in each of the ancestry populations and the trans-ancestry meta-analysis (OR(meta)=1.16, 95% CI 1.11 to 1.22; p=4.88×10(-10) and OR(meta)=1.67, 95% CI 1.55 to 1.79; p=3.32×10(-46), respectively).
|
22523428 |
2012 |
Sickle Cell-SS Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium.
|
20015873 |
2010 |
Thrombosis
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
LW protein: a promiscuous integrin receptor activated by adrenergic signaling.
|
16564726 |
2006 |
Malignant neoplasm of prostate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An ICAM gene cluster lying within a 26 kb region on chromosome 19p13.2, and containing ICAM1, ICAM4, and ICAM5 has recently been identified as harboring a breast and prostate cancer susceptibility locus in two populations of European ancestry from Germany and Australia.
|
16733712 |
2006 |
Prostate carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An ICAM gene cluster lying within a 26 kb region on chromosome 19p13.2, and containing ICAM1, ICAM4, and ICAM5 has recently been identified as harboring a breast and prostate cancer susceptibility locus in two populations of European ancestry from Germany and Australia.
|
16733712 |
2006 |
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified previously a region on chromosome 19p13.2 spanning the genes encoding the intercellular adhesion molecules (ICAM), ICAM1, ICAM4 and ICAM5 as a breast cancer susceptibility locus.
|
15774488 |
2005 |
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified previously a region on chromosome 19p13.2 spanning the genes encoding the intercellular adhesion molecules (ICAM), ICAM1, ICAM4 and ICAM5 as a breast cancer susceptibility locus.
|
15774488 |
2005 |