IDE, insulin degrading enzyme, 3416

N. diseases: 71; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0497327
Disease: Dementia
Dementia
0.050 GeneticVariation disease BEFREE Several mechanisms have been reported underlying the association of the two disorders, diabetes and dementia, one among which is the insulin-degrading enzyme (IDE) which is known to degrade insulin as well beta-amyloid peptides. 28137222 2017
CUI: C0497327
Disease: Dementia
Dementia
0.050 AlteredExpression disease BEFREE Results showed that the reduction in IDE and NGF expression in the hippocampus of pups might be associated with impairment of learning and memory and dementia induced by maternal lead exposure during pregnancy and lactation. 28427492 2017
CUI: C0497327
Disease: Dementia
Dementia
0.050 GeneticVariation disease BEFREE We sought to explore whether IDE genes play a role in the association of diabetes with dementia, AD, and structural brain changes using data from two community-based cohorts of older adults and a subsample with structural MRI. 26173052 2015
CUI: C0497327
Disease: Dementia
Dementia
0.050 Biomarker disease BEFREE Although evidence suggests that NEP is down-regulated in Alzheimer's disease (AD), the role of IDE and ECE in the Aβ accumulation in aging and dementia remains less certain. 20663017 2010
CUI: C0497327
Disease: Dementia
Dementia
0.050 GeneticVariation disease BEFREE There was no association of IDE haplotypes with the risk of dementia. 17192720 2006
CUI: C0497327
Disease: Dementia
Dementia
0.050 AlteredExpression disease LHGDN This study suggests IDE may be indirectly related to dementia via its regulation of insulin levels, but it is not a major gene for Alzheimer's. 17192720 2006