IDH1, isocitrate dehydrogenase (NADP(+)) 1, 3417

N. diseases: 399; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Mutations of NADP(+)-dependent isocitrate dehydrogenases encoded by IDH1 and IDH2 occur in a majority of several types of malignant gliomas. 19228619 2009
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 Biomarker disease CTD_human NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. 19901110 2009
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Similarly, in human malignant gliomas harbouring IDH1 mutations, we find markedly elevated levels of 2HG. 19935646 2009
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Polar spongioblastoma: A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH. 20102524 2010
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE IDH1 mutations are common in malignant gliomas in older children, suggesting that a subset of these lesions may be biologically similar to malignant gliomas arising in younger adults and may be associated with a more favorable prognosis. 20725730 2011
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 Biomarker disease BEFREE Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are found frequently in malignant gliomas and are likely involved in early gliomagenesis. 22136423 2012
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE The interesting identification of an IDH1 mutation in a radiation-induced secondary malignant glioma raises the likelihood that these types of tumor may develop IDH1/2 mutations. 22821382 2012
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. 22869205 2012
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE We investigated the expression of Sox11 in 132 diffuse astrocytomas in relation to the regulator cell marker nestin, c-Met and IDH1-R132H, which have shown to be differentially expressed among the molecular subgroups of malignant gliomas, as well as to an inducer of astrocytic differentiation, that is, signal transducer and activator of transcription (p-STAT-3), clinicopathological features and survival. 23619925 2013
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Of 158 tumors with sufficient tissue, 110 (70 %) showed nuclear cMYC immunopositivity--most frequent (95 %, χ(2) p = 0.0248) and intense (mean 1.33, ANOVA p = 0.0179) in anaplastic astrocytomas versus glioblastomas (63 %) or low grade gliomas (74 %). cMYC expression associated with younger age as well as p53 immunopositivity (OR = 3.6, p = 0.0332) and mutant IDH1 (R132H) (OR = 7.4, p = 0.06) among malignant gliomas in our cohort. 23934175 2013
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE To determine the prognostic value of isocitrate dehydrogenase 1 (IDH1) mutation, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, and 1p/19q co-deletion in Japanese patients with malignant gliomas. 24160898 2013
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 Biomarker disease BEFREE Recently, mutations of the ATRX gene have been found in various subtypes and grades of gliomas and were shown to refine the prognosis of malignant gliomas in combination with IDH and 1p/19q status. 24559763 2014
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Isocitrate dehydrogenase 1 gene (IDH1) R132H mutation status was also recently identified as a prognostic factor for malignant gliomas. 24929863 2014
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE The results of this study suggest that IDH1 mutation may be associated with polySia expression pathways in malignant gliomas. 25164322 2014
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE We identify miR148a as a novel, G-CIMP-associated miRNA whose methylation is tightly correlated with IDH1 mutation and associated with improved survival in patients with malignant glioma. 25224277 2014
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE The NRF2 activity is increased in a significant proportion of malignant gliomas in general but decreased in the majority of IDH1/2-mutant anaplastic gliomas. 25304134 2015
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 Biomarker disease CTD_human Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. 25391653 2015
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Recent investigations of malignant gliomas have identified additional genetic and chromosomal abnormalities which cluster with IDH1 mutations into two distinct subgroups. 25471051 2015
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 Biomarker disease CTD_human Mutational landscape and clonal architecture in grade II and III gliomas. 25848751 2015
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Patient 2, with malignant glioma with primitive neuroectodermal tumor (MGPNET), had a secondary GBM with a noncanonical isocitrate dehydrogenase 1 (IDH1) mutation and 11-year-survival; autopsy showed encasement of the entire bilateral ventricular system by SVS. 26308254 2016
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE It is proposed that isocitrate dehydrogenase 1 (IDH1) mutation predicts the outcome in patients with high-grade glioma. 26316565 2015
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 AlteredExpression disease BEFREE Classification based on IDH1/2 mutation status and Ki-67 expression level could be more convenient for clinical application and guide personalized treatment in malignant gliomas. 26338964 2015
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE Integrated genomic characterization of IDH1-mutant glioma malignant progression. 26618343 2016
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 Biomarker disease CTD_human Integrated genomic characterization of IDH1-mutant glioma malignant progression. 26618343 2016
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.400 GeneticVariation disease BEFREE En bloc resection revealed a high-grade glioma with sarcomatous components that was immunoreactive for the R132H variant of IDH1 by antibody. 27153165 2017