Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 GeneticVariation disease BEFREE Massively parallel paired-end sequencing of whole genomes of 10 primary chondrosarcomas revealed that the process of accumulation of somatic mutations is homogeneous irrespective of the pathological subtype or the presence of IDH1 mutations, is unique among a range of cancer types, and shares significant commonalities with that of prostate cancer. 25024164 2014
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 GeneticVariation disease BEFREE Most recent studies suggested that IDH1 mutations define a methylator subtype in PCa. 29331887 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 AlteredExpression disease BEFREE Overall, our study demonstrates that <i>IDH1</i> expression is associated with prostate cancer progression, that AR signaling integrates one of the first transcriptional mechanisms shown to regulate <i>IDH1</i>, and that AR reprograms prostate cancer cell metabolism by selectively inducing extra-mitochondrial IDH activity. 31068457 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 GeneticVariation disease BEFREE SPOP, FOXA1, and IDH1 mutations are other three main oncogenic driver subclasses in non-ETS-fusion PrCa. 31090082 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Biomarker disease CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 GeneticVariation disease BEFREE This high degree of heterogeneity may profoundly limit therapeutic targeting of IDH1 mutations in prostate cancer. 29427004 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 GeneticVariation disease BEFREE This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion. 31846689 2020
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 GeneticVariation disease BEFREE This study suggests that despite the infrequent incidence of the IDH1 mutations in prostate cancers and B-ALL, mutated IDH1 could be therapeutically targeted in these cancers and in glial tumors with the IDH1 mutations. 19378339 2009