Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 GeneticVariation disease BEFREE We also identify negative associations (odds ratio < 1) between mutational signatures and driver mutations, and here we examine the role of aging and cigarette smoke mutagenesis in the generation of driver mutations in IDH1 and KRAS in brain cancers and lung adenocarcinomas respectively. 30412573 2018
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 GeneticVariation disease BEFREE Mutations of the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are commonly found in primary brain cancers. 22015945 2012
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 GeneticVariation disease BEFREE These findings indicate that ZX06 deserves further optimization as a lead compound for the treatment of patients with IDH1 mutated brain cancers. 29290542 2018
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 GeneticVariation disease BEFREE IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. 20160062 2010
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 GeneticVariation disease BEFREE Mutations in the isocitrate dehydrogenase 1 (IDH1) gene have been identified in a number of cancer types, including brain cancer. 29849122 2018
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 GeneticVariation disease BEFREE These findings indicate that 3g deserves further optimization as a lead compound for the treatment of patients with IDH1 mutated brain cancers. 29089260 2017
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 Biomarker disease BEFREE Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. 19935646 2009
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 Biomarker disease BEFREE There is mounting clinical evidence that the mutational status of cancer driver genes such as KRAS or IDH1 may influence the risk of venous thromboembolism in patients with colorectal, lung or brain cancers. 29703472 2018
CUI: C0153633
Disease: Malignant neoplasm of brain
Malignant neoplasm of brain
0.380 CausalMutation disease CGI