IDH1, isocitrate dehydrogenase (NADP(+)) 1, 3417

N. diseases: 399; N. variants: 10
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 AlteredExpression disease BEFREE Although IDH1 and B7H3 cannot be used as independent prognostic factors, co-expression of IDH1 and B7H3 significantly correlated with the prognosis of CRC patients and may serve as a combined predictive marker. 29871819 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 Biomarker disease BEFREE Our study indicates the antitumor properties of M<sub>4</sub>IDP and its potential clinical use in CRC therapy by blocking PI3K/Akt/mTOR pathway. 28751160 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease BEFREE In both gastric and colorectal cancer, expression of IDH1-R132H was associated with tumor stage. 27655638 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease BEFREE Rare mutations not typically associated with CRC included AKT1 (4), AKT2 (1), IDH1 (1), KIT (1), MAP2K1 (1), PTEN (2), and GNAS (6). 25683705 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 AlteredExpression disease BEFREE The present computational analysis revealed a novel and potential mechanism of CRC development, through over-production of D2HG when there is an imbalance between IDH1 and IDH2 expression, resulting in decreased clearance of D2HG when the β-oxidization pathway is diminished. 25586680 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease BEFREE We therefore examined IDH1 alteration as a potential cause of CIMP in colorectal cancer. 25496513 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease UNIPROT