Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gliomas in people with NF1 show alterations in the RAS/MAPK pathway, generally in the absence of BRAF alterations (common to sporadic pilocytic astrocytomas) or IDH or histone H3 mutations (common to diffuse gliomas subsets).
|
30963251 |
2020 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reports of IDH-1 and IDH-2 alterations in pilocytic astrocytomas have been rare.
|
31677487 |
2019 |
Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among glioma subtypes, activating FGFR1 alterations have been observed in a subpopulation of pilocytic astrocytomas while FGFR3 fusions occur in IDH wild-type diffuse gliomas, resulting in high FGFR3 protein expression.
|
28468611 |
2017 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study we searched for FGFR1-ITD by droplet digital PCR (DDPCR™) and for FGFR1 point mutations by HRM-sequencing in a series of formalin-fixed paraffin-embedded (FFPE) LGNTs including 12 DNT, 2 oligodendrogliomas lacking IDH mutation and 1p/19q co- deletion (pediatric-type oligodendrogliomas; PTOs), 3 pediatric diffuse astrocytomas (PDAs), 14 gangliogliomas (GGs) and 5 pilocytic astrocytomas (PAs).
|
27791984 |
2017 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A subtype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-type diffuse glioma showed molecular similarity to pilocytic astrocytoma and relatively favorable survival.
|
26824661 |
2016 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined 170 (0-18 years) pediatric and 131 (19-35 years) young adult brain tumors including pilocytic astrocytomas (PAs), pilomyxoid astrocytomas (PMAs), diffuse astrocytomas (DAs), gangliogliomas, dysembryoplastic neuroepithelial tumors (DNTs) and pleomorphic xanthoastrocytomas (PXAs) for IDH1 and BRAF mutation/BRAF fusion gene status.
|
26115961 |
2016 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IDH1 R132H mutation in a pilocytic astrocytoma: a case report.
|
26617931 |
2015 |
Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wild-type (WT) IDH1 was detected in cases with a World Health Organization (WHO) grade I astrocytoma.
|
23934769 |
2014 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study identified the expression of KIAA1549-BRAF fusion gene and BRAF V600E mutation, mutations at exon 4 of the IDH1 and IDH2 genes in samples of pilocytic astrocytomas (PA) and grade-II astrocytomas (A-II) pediatric patients.
|
24532263 |
2014 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A pilocytic astrocytoma (PA I) and a glioblastoma multiforme (GBM IV) showed low-abundance IDH1 mutations detected by COLD-PCR/FMCA.
|
23370430 |
2013 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, ten PAs with atypical clinicoradiologic and histologic features and six pediatric glioblastoma multiforme (pGBMs) were analyzed for BRAF V600E, IDH1, IDH2, and TP53 mutations.
|
24057326 |
2013 |
Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Different molecular biomarkers were identified by genetic studies and some of these are used in neuro-oncology for the evaluation of glioma patients, in particular combined deletions of the chromosome arms 1p and 19q in oligodendroglial tumors, methylation status of the O-6 methylguanine- DNA methyltransferase gene promoter and alterations in the epidermal growth factor receptor pathway in adult malignant gliomas, isocitrate dehydrogenase 1 (IDH1) and IDH2 gene mutations in diffuse gliomas, as well as BRAF status in pilocytic astrocytomas.
|
22617234 |
2012 |
Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This review summarizes recent studies on diagnostic and prognostic markers in gliomas such as the BRAF fusion gene in pilocytic astrocytomas and 1p/19q codeletion, O-6-methylguanine-DNA methyltransferase status and isocitrate dehydrogenase 1 (IDH1)/IDH2 mutations in diffuse gliomas.
|
19667985 |
2009 |
Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, combined molecular analysis of BRAF and IDH1 is a sensitive and highly specific approach to separate pilocytic astrocytoma from diffuse astrocytoma.
|
19543740 |
2009 |