IDH1, isocitrate dehydrogenase (NADP(+)) 1, 3417

N. diseases: 399; N. variants: 10
Disease: Biliary Tract Cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0750952
Disease: Biliary Tract Cancer
Biliary Tract Cancer 		0.050 GeneticVariation disease BEFREE However, it is reasonable to assume that the clinical utility could be optimized in this patient group by extending the panel to include BTC specific mutations with potential therapeutic consequences such as IDH1/2, FGFR fusions, ERBB3, and BRCA1/2. 31628675 2020
CUI: C0750952
Disease: Biliary Tract Cancer
Biliary Tract Cancer 		0.050 Biomarker disease BEFREE To identify new biomarkers for BTCs, we performed Robust Rank Aggreg (RRA) analysis and identified that IDH1 mutation was common in ICC, while IDH1<sup>R132C</sup> was the most frequent type. 30889491 2019
CUI: C0750952
Disease: Biliary Tract Cancer
Biliary Tract Cancer 		0.050 Biomarker disease BEFREE Recent and ongoing investigations into IDH inhibitors for advanced and metastatic BTCs are also discussed. 30352944 2019
CUI: C0750952
Disease: Biliary Tract Cancer
Biliary Tract Cancer 		0.050 Biomarker disease BEFREE Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. 25043045 2014
CUI: C0750952
Disease: Biliary Tract Cancer
Biliary Tract Cancer 		0.050 GeneticVariation disease BEFREE IDH mutations in liver cell plasticity and biliary cancer. 25485496 2014