Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0860564
Disease: Retinoic acid syndrome
Retinoic acid syndrome
0.040 Biomarker disease BEFREE Unexpected adverse events of IDH-DS during the phase 1/2 study. 29346478 2018
CUI: C0860564
Disease: Retinoic acid syndrome
Retinoic acid syndrome
0.040 Biomarker disease BEFREE Enasidenib was well tolerated, although adverse events of clinical interest include indirect hyperbilirubinemia and IDH-inhibitor-induced differentiation syndrome, which can be life threatening if not identified and treated promptly. 30013764 2018
CUI: C0860564
Disease: Retinoic acid syndrome
Retinoic acid syndrome
0.040 Biomarker disease BEFREE Grade 3 to 4 enasidenib-related adverse events included indirect hyperbilirubinemia (12%) and IDH-inhibitor-associated differentiation syndrome (7%). 28588020 2017
CUI: C0860564
Disease: Retinoic acid syndrome
Retinoic acid syndrome
0.040 GeneticVariation disease BEFREE We describe 3 patients who developed clinically apparent DS during monotherapy with the mutant IDH1 inhibitor, AG-120, for relapsed/refractory AML. 27245312 2016