Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For this reason, it was suggested that immunohistochemistry against IDH1 R132H is sufficient to classify GBM as IDH wild-type in this age group.
|
31758617 |
2020 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This effect was not observed in patients with IDH1 mutant (IDH1Mut) GBM.
|
31746408 |
2020 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
67 patients aged 70 years or younger, operated between January 2013 and December 2015, with newly diagnosed IDH wild-type GBM and clinical follow-up were retrospectively investigated in this study.
|
31422371 |
2020 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
U87 human GBM cells were treated with the IC50 concentration of various agents used in the treatment of GBM, including alkylating agents (temozolomide, carmustine, lomustine, procarbazine), inhibitor of topoisomerase I (irinotecan), vascular endothelial and epidermal growth factor receptor inhibitors (cediranib and erlotinib, respectively) anti-metabolite (5-fluorouracil), microtubule inhibitor (vincristine), and metabolic agents (dichloroacetate and IDH1 inhibitor ivosidenib).
|
30989436 |
2020 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Continuous administration of DS-1001b impaired tumor growth and decreased 2-HG levels in subcutaneous and intracranial xenograft models derived from a glioblastoma patient with IDH1 mutation.
|
31727689 |
2020 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
Predicting TERT promoter mutation using MR images in patients with wild-type IDH1 glioblastoma.
|
30948344 |
2020 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In application to the glioblastoma dataset from The Cancer Genome Atlas, MHN proposed a novel interaction in line with consecutive biopsies: IDH1 mutations are early events that promote subsequent fixation of TP53 mutations.
|
31250881 |
2020 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Anaplastic astrocytoma, IDH-wildtype (AA-IDHwt) was the common molecular subgroup (52.8%), followed by diffuse astrocytoma, IDH-wildtype (DA-IDHwt) and AA, IDH-mutant (AA-IDHmt) (each 16.9%), DA-IDHmt (7.9%), glioblastoma (GBM)-IDHwt (3.3%) and GBM-IDHmt (2.2%).
|
31435963 |
2020 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IDH1 mutations are closely related to the development and progression of various human cancers, such as glioblastoma, sarcoma, and acute myeloid leukemia.
|
31836442 |
2020 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
IDH-wild-type glioblastoma (GBM) is a disease with devastating prognosis.
|
31736002 |
2020 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Prognostic significance of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and isocitrate dehydrogenase-1 (IDH-1) mutation in glioblastoma multiforme patients: A single-center experience in the Middle East region.
|
31108342 |
2019 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The histomolecular profile appears to be different from that of supratentorial gliomas, with no IDH1/2 gene mutations and only 1 case with a classic profile of de novo glioblastoma.
|
29809131 |
2019 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Patients with IDH wild type anaplastic astrocytoma and glioblastoma had a significantly shorter median PFS (19.3 months vs. NR, p = 0.001) and median OS (43.5 months vs NR, p = 0.007) than those with IDH mutated grade III anaplastic astrocytoma and oligodendroglioma.
|
31371189 |
2019 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
Consequently, we present a curated panel of 12 readily-usable, genetically-diverse, tumourigenic, patient-derived, low-passage, serum-free cell lines representing the spectrum of molecular subtypes of IDH-wildtype GBM along with their detailed phenotypic characterisation plus a bespoke set of lentiviral plasmids for bioluminescent/fluorescent labelling, gene expression and CRISPR/Cas9-mediated gene inactivation.
|
30894629 |
2019 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An analysis of 2589 patient samples showed that CLEC5A expression is higher in (1) glioblastoma than in lower-grade glioma and nontumor tissue, (2) in the mesenchymal subtype than in other subtypes, and (3) in IDH1-wild type glioblastoma than in IDH1-mutated glioblastoma.
|
31591460 |
2019 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In both the GBM and LGG cohort study, most of the patients in the high-risk group had the IDH1 wild-type gene, and those in the low-risk group had IDH1 mutations.
|
30894197 |
2019 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
Moreover, HLA-F was enriched in GBM and isocitrate dehydrogenase 1 wild-type (IDH1 wt) group and considered HLA-F as a mesenchymal subtype marker.
|
30755240 |
2019 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The autoradiographic study shows the entirely higher radioactivity of the U251/IDH1 R132H tumor tissue section than that of the U251/IDH1 Wild-type tumor.
|
31667733 |
2019 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
We studied the association of immunohistochemical expression of hypoxia inducible factor-1 alpha (HIF-1α), telomerase reverse transcriptase (TERT), isocitrate dehydrogenase 1 (IDH1) and tumor protein p53 with overall survival (OS) in glioblastoma patients uniformly treated by standard of care, with adequate follow-up.
|
31258744 |
2019 |
Glioblastoma Multiforme
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the concordance of low ALDOC and high non-mutated IDH1 expressions predicted a stronger poor prognosis in glioblastoma patients compared to each of above tests presented alone.
|
31450822 |
2019 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent DNA methylation analyses revealed a small group of IDH mutant diffuse gliomas exhibiting decreased DNA hypermethylation resulting in substantial unfavorable prognosis comparable to glioblastoma.
|
30937703 |
2019 |
Glioblastoma Multiforme
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Widely metastatic IDH1-mutant glioblastoma with oligodendroglial features and atypical molecular findings: a case report and review of current challenges in molecular diagnostics.
|
30738431 |
2019 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
From Jan 2009 to Dec 2016, 161 patients with newly diagnosed IDH-wild type GB were treated with surgery and adjuvant concurrent chemoradiotherapy with the Stupp's regimen, and then genomic research proceeded with their surgical specimens.
|
30773189 |
2019 |
Glioblastoma Multiforme
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found that ADAMTSL4 was enriched in GBM (WHO grade IV), especially for those with IDH1/2 wild-type and MGMT unmethylated groups.
|
30728876 |
2019 |
Glioblastoma Multiforme
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
<b>Abbreviations</b>: AAAIR: Average Annual Age-Adjusted Incidence Rate; AI/AN: American Indian or Alaska Native; API: Asian or Pacific Islander; CBTRUS: Central Brain Tumor Registry of the United States; CUMC: Columbia University Medical Center; EOR: Extent of Resection; Exc: Excluded; GBM: Glioblastoma; GTR: Gross Total Resection; IDH-1: Isocitrate Dehydrogenase 1; MGMT: O6-Methylguanine DNA Methyltransferase; NCDB: National Cancer Database; OS: Overall Survival; O/U: Other/Unknown; PFS: Progression-Free Survival; SEER: Surveillance, Epidemiology, and End Results; S&W BTR: Scott & White Brain Tumor Registry; UCLA: University of California Los Angeles; UM: University of Miami.
|
31271539 |
2019 |