For instance, mutations in the <i>isocitrate dehydrogenase 1 (IDH1)</i> gene, which occurs in a subgroup of glioma, correlate with risk of VTE, with low incidence in patients with presence of an <i>IDH1</i> mutation compared with those with <i>IDH1</i> wild-type status.
Patients with wild-type IDH1 brain tumors and high podoplanin expression had a significantly increased VTE risk compared with those with mutant IDH1 tumors and no podoplanin expression (6-month risk 18.2% vs. 0%).
There is mounting clinical evidence that the mutational status of cancer driver genes such as KRAS or IDH1 may influence the risk of venous thromboembolism in patients with colorectal, lung or brain cancers.