Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
False positive mismatch sign was noted in 28.5% (12/42) Group O tumors, but none of the tumors in Group G. A combination of all three factors: age under 40 years at first diagnosis, a tumor size larger than 6 cm and T2-FLAIR mismatch was highly specific for IDH mutant astrocytoma (Group A).
|
30536195 |
2019 |
Childhood Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, we found two genetic/clinical correlations that must be evaluated to understand their impact in the clinical setting: i) how is PTEN deletion a favorable prognostic factor in GBM IDH wildtype and an unfavorable prognostic factor in astrocytoma IDH wildtype and ii) how EGFR amplification is an independent and strong factor of response to radiotherapy.
|
31623593 |
2019 |
Childhood Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Multivariate analysis further revealed that prognosis of astrocytoma was significantly associated with Sp1 expression (p = 0.036) and IDH-1 expression (p < 0.001).
|
29948615 |
2019 |
Childhood Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Shorter PFS was associated with the astrocytoma IDH-wildtype subtype despite similar extent of resection and adjuvant treatment rates compared to the other subtypes.OS did not differ between subtypes.
|
30498891 |
2019 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 135 cases consisted of 38 IDH-mutant [17 astrocytoma (AC), 13 oligodendroglioma (OD) and eight glioblastoma (GBM)], 87 IDH-wildtype (six AC, three OD and 78 GBM), and 10 diffuse midline glioma, H3K27M-mutant.
|
30710203 |
2019 |
Childhood Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using an integrated functional genomics approach, we prioritized networks associated with astrocytoma progression using the following criteria: differential co-expression between grade II and grade III IDH1-mutated and 1p/19q euploid astrocytomas, preferential enrichment for genetic risk to cancer, association with patient survival and sample-level genomic features.
|
31420939 |
2019 |
Childhood Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Median OS was similar for IDH1/2wt astrocytoma WHO IV patients (23.8 months) and IDH1/2wt glioblastoma patients (19.2 months) (Cox proportional hazard model: hazard ratio (HR) 1.27, 95% confidence interval (CI) 0.85-1.88, p=0.242).
|
31637414 |
2019 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Copy number variation (CNV) abundance associated with survival in low-grade and IDH mutant astrocytoma has been reported.
|
31134296 |
2019 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the mutation load was similar, as was the methylation pattern, being consistent with IDH-mutant astrocytoma.
|
29741737 |
2018 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of these, we recommend, OA,NOS and IDH1(R132H)-non-mt ODG,NOS to be our priority for performing 1p/19q co-deletion studies in comparison to IDH-mt ODG,NOS, and it would not be mandatory for astrocytoma.
|
28801347 |
2018 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, later genome-wide methylation profiling of the diagnostic tumor undertaken to guide treatment, revealed characteristics most consistent with IDH-mutant astrocytoma.
|
28993028 |
2018 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Trisomy of chromosome 7 in IDH mutated astrocytoma and PTEN mutations in IDH mutated oligodendroglioma are potential markers of poor prognosis, but require confirmation in larger series.
|
29663171 |
2018 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
36 (57%) had oligodendroglioma and 27 astrocytoma.IDH-1 mutation was present in 53 (84%).
|
30292978 |
2018 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both 3D pCASL and DWI could be useful tools for distinguishing low- from high-grade diffuse gliomas and have the potential to differentiate different IDH1 mutation statuses of astrocytoma.
|
29777252 |
2018 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients.
|
30071292 |
2018 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
|
28124097 |
2017 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The NGS approach was effective in reclassifying 36 oligoastrocytomas as 30 astrocytomas (20 IDH1/2 mutant and 10 IDH1/2 wild type) and 6 oligodendrogliomas, and 1 oligodendroglioma as an astrocytoma (IDH1/2 mutant).
|
28042970 |
2017 |
Childhood Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meanwhile, the results from immunohistochemistry and DNA sequencing showed that, compared with primary astrocytoma, there was no change of IDH1 status in recurrent astrocytoma whatever tumour pathological grade raise or indolent.
|
28928859 |
2017 |
Childhood Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our proteomic datasets are available for download and provide a comprehensive catalogue of alterations in protein abundance, phosphorylation, and histone modifications in oncogenic HRAS and IDH1 driven astrocytoma cells beyond the transcriptomic level.
|
27834733 |
2017 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IDH1 gene mutant and wildtype groups of WHO grade II, III, and IV astrocytoma showed differences in the rCBV ratio (P = 0.005, 0.045, and 0.005, respectively).
|
27367599 |
2017 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Distinct spectral profiles were observed for lesions with IDH-mutated genotypes, between astrocytoma and oligodendroglioma histologies, as well as for tumors that had undergone MP.
|
28327577 |
2017 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.
|
27460417 |
2016 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data reveal that the methylation profiles in 23 of the 25 GC tumors corresponded to either IDH mutant astrocytoma (n = 6), IDH mutant and 1p/19q codeleted oligodendroglioma (n = 5), or IDH wild-type glioblastoma including various molecular subgroups, i.e., H3F3A-G34 mutant (n = 1), receptor tyrosine kinase 1 (RTK1, n = 4), receptor tyrosine kinase 2 (classic) (RTK2, n = 2) or mesenchymal (n = 5) glioblastoma groups.
|
26493382 |
2016 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma.
|
25427834 |
2015 |
Childhood Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with astrocytoma, the TERT promoter mutations only associated with poor survival (P < 0.0001); IDH mutations and 1p/19q deletions associated with increased survival (P = 0.0004).
|
25797251 |
2015 |