Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE False positive mismatch sign was noted in 28.5% (12/42) Group O tumors, but none of the tumors in Group G. A combination of all three factors: age under 40 years at first diagnosis, a tumor size larger than 6 cm and T2-FLAIR mismatch was highly specific for IDH mutant astrocytoma (Group A). 30536195 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 Biomarker disease BEFREE Moreover, we found two genetic/clinical correlations that must be evaluated to understand their impact in the clinical setting: i) how is PTEN deletion a favorable prognostic factor in GBM IDH wildtype and an unfavorable prognostic factor in astrocytoma IDH wildtype and ii) how EGFR amplification is an independent and strong factor of response to radiotherapy. 31623593 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 AlteredExpression disease BEFREE Multivariate analysis further revealed that prognosis of astrocytoma was significantly associated with Sp1 expression (p = 0.036) and IDH-1 expression (p < 0.001). 29948615 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 Biomarker disease BEFREE Shorter PFS was associated with the astrocytoma IDH-wildtype subtype despite similar extent of resection and adjuvant treatment rates compared to the other subtypes.OS did not differ between subtypes. 30498891 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE A total of 135 cases consisted of 38 IDH-mutant [17 astrocytoma (AC), 13 oligodendroglioma (OD) and eight glioblastoma (GBM)], 87 IDH-wildtype (six AC, three OD and 78 GBM), and 10 diffuse midline glioma, H3K27M-mutant. 30710203 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 AlteredExpression disease BEFREE Using an integrated functional genomics approach, we prioritized networks associated with astrocytoma progression using the following criteria: differential co-expression between grade II and grade III IDH1-mutated and 1p/19q euploid astrocytomas, preferential enrichment for genetic risk to cancer, association with patient survival and sample-level genomic features. 31420939 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 Biomarker disease BEFREE Median OS was similar for IDH1/2wt astrocytoma WHO IV patients (23.8 months) and IDH1/2wt glioblastoma patients (19.2 months) (Cox proportional hazard model: hazard ratio (HR) 1.27, 95% confidence interval (CI) 0.85-1.88, p=0.242). 31637414 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Copy number variation (CNV) abundance associated with survival in low-grade and IDH mutant astrocytoma has been reported. 31134296 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE In contrast, the mutation load was similar, as was the methylation pattern, being consistent with IDH-mutant astrocytoma. 29741737 2018
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Of these, we recommend, OA,NOS and IDH1(R132H)-non-mt ODG,NOS to be our priority for performing 1p/19q co-deletion studies in comparison to IDH-mt ODG,NOS, and it would not be mandatory for astrocytoma. 28801347 2018
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE However, later genome-wide methylation profiling of the diagnostic tumor undertaken to guide treatment, revealed characteristics most consistent with IDH-mutant astrocytoma. 28993028 2018
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Trisomy of chromosome 7 in IDH mutated astrocytoma and PTEN mutations in IDH mutated oligodendroglioma are potential markers of poor prognosis, but require confirmation in larger series. 29663171 2018
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE 36 (57%) had oligodendroglioma and 27 astrocytoma.IDH-1 mutation was present in 53 (84%). 30292978 2018
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Both 3D pCASL and DWI could be useful tools for distinguishing low- from high-grade diffuse gliomas and have the potential to differentiate different IDH1 mutation statuses of astrocytoma. 29777252 2018
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients. 30071292 2018
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo. 28124097 2017
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE The NGS approach was effective in reclassifying 36 oligoastrocytomas as 30 astrocytomas (20 IDH1/2 mutant and 10 IDH1/2 wild type) and 6 oligodendrogliomas, and 1 oligodendroglioma as an astrocytoma (IDH1/2 mutant). 28042970 2017
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 Biomarker disease BEFREE Meanwhile, the results from immunohistochemistry and DNA sequencing showed that, compared with primary astrocytoma, there was no change of IDH1 status in recurrent astrocytoma whatever tumour pathological grade raise or indolent. 28928859 2017
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 AlteredExpression disease BEFREE Our proteomic datasets are available for download and provide a comprehensive catalogue of alterations in protein abundance, phosphorylation, and histone modifications in oncogenic HRAS and IDH1 driven astrocytoma cells beyond the transcriptomic level. 27834733 2017
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE The IDH1 gene mutant and wildtype groups of WHO grade II, III, and IV astrocytoma showed differences in the rCBV ratio (P = 0.005, 0.045, and 0.005, respectively). 27367599 2017
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Distinct spectral profiles were observed for lesions with IDH-mutated genotypes, between astrocytoma and oligodendroglioma histologies, as well as for tumors that had undergone MP. 28327577 2017
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma. 27460417 2016
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE Our data reveal that the methylation profiles in 23 of the 25 GC tumors corresponded to either IDH mutant astrocytoma (n = 6), IDH mutant and 1p/19q codeleted oligodendroglioma (n = 5), or IDH wild-type glioblastoma including various molecular subgroups, i.e., H3F3A-G34 mutant (n = 1), receptor tyrosine kinase 1 (RTK1, n = 4), receptor tyrosine kinase 2 (classic) (RTK2, n = 2) or mesenchymal (n = 5) glioblastoma groups. 26493382 2016
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma. 25427834 2015
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma
0.100 GeneticVariation disease BEFREE In patients with astrocytoma, the TERT promoter mutations only associated with poor survival (P < 0.0001); IDH mutations and 1p/19q deletions associated with increased survival (P = 0.0004). 25797251 2015