IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Binding studies indicated the presence of 2,980 +/- 170 receptors per cell, each with an apparent Kd of (8.4 +/- 1.3) X 10(-11) M. Results from competitive binding studies suggested that Hs294T cells possess at least two types of IFN receptors: one which binds IFN-alpha A and IFN-beta 1 and another to which IFN-gamma binds. 6319748 1984
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.070 Biomarker disease BEFREE Mouse IFN inhibited the development of transformed foci in NIH 3T3 cultures transfected with the viral Ha-MuSV(ras) and Mo-MuSV(mos) oncogenes, or with the human bladder carcinoma ras EJ/T24 DNA. 3970704 1985
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 Biomarker disease BEFREE These findings suggest that MNC of patients with SLE have defects in the IL-2 signal transduction which is required for production of gamma-IFN. 2429672 1986
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.090 Biomarker disease BEFREE These findings indicate that rec gamma-IFN can modulate the excessive collagen biosynthesis characteristic of PSS fibroblasts and that this effect can be explained largely by the gamma-IFN-mediated decrease in specific collagen mRNAs. 3091039 1986
CUI: C0019159
Disease: Hepatitis A
Hepatitis A 		0.090 Biomarker disease BEFREE In an effort to define immunobiological parameters identifying "responders" vs "non-responders" to IFN among hepatitis patients, 16 patients with chronic active hepatitis were screened for changes of Natural Killer cell activity (NK). 2461050 1988
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.080 Biomarker disease BEFREE The potent effect of IFN suggests a role for these modulators in NB behaviour in vivo. 3243386 1988
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.070 Biomarker disease BEFREE The potent effect of IFN suggests a role for these modulators in NB behaviour in vivo. 3243386 1988
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.070 Biomarker disease BEFREE The potent effect of IFN suggests a role for these modulators in NB behaviour in vivo. 3243386 1988
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.060 Biomarker group BEFREE In an effort to define immunobiological parameters identifying "responders" vs "non-responders" to IFN among hepatitis patients, 16 patients with chronic active hepatitis were screened for changes of Natural Killer cell activity (NK). 2461050 1988
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.030 Biomarker disease BEFREE The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. 2484652 1988
CUI: C0023443
Disease: Hairy Cell Leukemia
Hairy Cell Leukemia 		0.020 Biomarker disease BEFREE The number of IFN-gamma receptors on our patient's MNCs was four times higher than the number of IFN-alpha receptors and was similar to the number of IFN-alpha receptors on MNCs from HCL patients responsive to IFN-alpha. 2846090 1988
CUI: C0702159
Disease: Constitutional aplastic anemia
Constitutional aplastic anemia 		0.010 Biomarker disease BEFREE The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. 2484652 1988
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.100 Biomarker disease BEFREE Such findings reveal that the effect of alpha-2-IFN in CML patients can be unexpectedly prolonged after discontinuance of treatment. 2792317 1989
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis 		0.020 AlteredExpression disease BEFREE This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis. 2757963 1989
CUI: C1852502
Disease: CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT
CRANIOMETAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT 		0.010 AlteredExpression disease BEFREE This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis. 2757963 1989
CUI: C1861922
Disease: CAMPOMELIC DYSPLASIA
CAMPOMELIC DYSPLASIA 		0.010 AlteredExpression disease BEFREE This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis. 2757963 1989
CUI: C2827469
Disease: Coronary Microvascular Disease
Coronary Microvascular Disease 		0.010 AlteredExpression disease BEFREE This study demonstrates that IFN has definite therapeutic activity in CMD with excessive thrombocytosis. 2757963 1989
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Therefore, the level of Mx-homologous protein induced during IFN therapy is not a predictive marker for an antitumor response in malignant melanoma. 1701809 1990
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE The unique de novo and IFN-modified antigenic phenotype of cultures derived from different patients indicates that the antigenic phenotype displayed by melanoma cultures grown in vitro is genetically determined. 2118485 1990
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.100 Biomarker disease BEFREE Interferon-alpha (1,000 U/ml) reduced the effects of the CML myeloid cell cytoplasmic protein on the electrophoretic mobility of nuclear protein-DNA complexes. 2243138 1990
CUI: C0524909
Disease: Hepatitis B, Chronic
Hepatitis B, Chronic 		0.100 Biomarker disease BEFREE In a randomized controlled trial of recombinant alpha-2a interferon for chronic hepatitis B, interferon antibodies developed in 21 (39%) of 54 Chinese adults who received IFN. 2258142 1990
CUI: C0275524
Disease: Coinfection
Coinfection 		0.080 Biomarker phenotype BEFREE HIV-1 infection did not stimulate constitutive production of endogenous IFN-alpha 1/alpha 2 or IFN-beta genes, although induction of IFN RNA was observed following coinfection with the paramyxovirus Sendai. 1699354 1990
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.070 Biomarker disease BEFREE Scanning densitometry and restriction fragment length polymorphism analysis were used to study the alpha-, beta-, gamma-, and omega-interferon (IFN) genes in malignant cells from 11 children with acute lymphocytic leukemia and in one cell line of T-cell origin. 1701354 1990
CUI: C0266999
Disease: Vesicular Stomatitis
Vesicular Stomatitis 		0.050 Biomarker disease BEFREE The antiviral function of IFN, as tested by inhibition by vesicular stomatitis virus (VSV) infection, and the IFN-receptor binding are not suppressed. 2153074 1990
CUI: C0010823
Disease: Cytomegalovirus Infections
Cytomegalovirus Infections 		0.030 AlteredExpression group BEFREE Secretion by peripheral blood mononuclear cells is increased if they are cultured with host fibroblasts infected with CMV in vitro and the levels of gamma IFN and TNF produced are within the range that protects fresh fibroblasts from CMV infection. 2168224 1990