IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Disease: Acute intermittent porphyria ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0162565
Disease: Acute intermittent porphyria
Acute intermittent porphyria 		0.020 Biomarker disease BEFREE Induction of severe AIP in mice with 10 µg of poly (I:C) was associated with pancreatic accumulation of pDCs producing IFN-α and IL-33 in the co-housing and FMT experiments. 31287532 2019
CUI: C0162565
Disease: Acute intermittent porphyria
Acute intermittent porphyria 		0.020 Biomarker disease BEFREE These data thus suggest that pDCs producing IFN-α and IL-33 play a pivotal role in the chronic fibro-inflammatory responses underlying murine AIP and human IgG4-related AIP. 28373582 2017