IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0275524
Disease: Coinfection
Coinfection
0.080 Biomarker phenotype BEFREE Additionally, we showed TRIMα and TRIM22 positively correlated with IFN-α, -β, which could be dysregulated by HIV, HCV mono- and co-infection. 26519943 2016
CUI: C0275524
Disease: Coinfection
Coinfection
0.080 Biomarker phenotype BEFREE These findings indicate that coinfection is associated with a type 1 IFN monocyte activation profile which was further found to correlate with cognitive impairment, even in subjects with controlled HIV infection. 23437063 2013
CUI: C0275524
Disease: Coinfection
Coinfection
0.080 AlteredExpression phenotype BEFREE Quantitative gene expression analysis revealed HIV-induced up regulation of most tested IFN family genes when compared to HCV or co-infection. 22825812 2012
CUI: C0275524
Disease: Coinfection
Coinfection
0.080 Biomarker phenotype BEFREE Coinfection resulted in greater type I and II IFN production in the lung compared with that with virus infection alone. 21178015 2011
CUI: C0275524
Disease: Coinfection
Coinfection
0.080 Biomarker phenotype BEFREE Recent therapeutic approaches against HIV-1 include IFN in combination therapy for patients with coinfections or as an alternative strategy against the virus. 21294215 2011
CUI: C0275524
Disease: Coinfection
Coinfection
0.080 AlteredExpression phenotype BEFREE The findings suggest the possibility that co-infection by serologically-silent HBV is one of the factors that can lead to an unfavorable IFN response in chronic hepatitis C by down-regulation of IFN receptor gene expression in the liver. 11170061 2001
CUI: C0275524
Disease: Coinfection
Coinfection
0.080 Biomarker phenotype BEFREE Patients with low pretreatment levels of HBV DNA cleared virus more frequently, and the response of precore mutant to IFN was comparable with that of wild-type HBV in patients who had a mixed infection. 8745316 1995
CUI: C0275524
Disease: Coinfection
Coinfection
0.080 Biomarker phenotype BEFREE HIV-1 infection did not stimulate constitutive production of endogenous IFN-alpha 1/alpha 2 or IFN-beta genes, although induction of IFN RNA was observed following coinfection with the paramyxovirus Sendai. 1699354 1990