IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.340 Biomarker disease BEFREE The aim of this study was to evaluate the effects of IFN-α-2b treatment supplemented with vitamin K<sub>2</sub> in the early stages of liver cancer development in rats. 30496957 2019
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.340 Biomarker disease BEFREE In particular, besides some cytokines like IFN-α and IL-2, several Toll-like receptor (TLR) agonists like BCG, MPL, and imiquimod are also licensed to be used in patients with several malignancies nowadays, and the first artificial small noncoding RNA (microRNA) mimic, MXR34, has entered phase I clinical study against liver cancer, implying their potential application in cancer therapy. 27240457 2016
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.340 Biomarker disease BEFREE In summary, our results identify central molecules mediating IFN-alpha induced apoptosis in liver tumors, shed light on the differential response of hepatoma cells to IFN exposure and, thus, may contribute to an efficient application of this substance in the treatment of liver cancer. 19141642 2009
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.340 GeneticVariation disease BEFREE Productive infections have been achieved recently with genotype 2a virus, but cirrhosis and liver cancer are typically associated with genotype 1 HCV, which is more prevalent and relatively resistant to IFN therapy. 16461899 2006
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.340 Therapeutic disease CTD_human IFN-alpha prevents the growth of pre-neoplastic lesions and inhibits the development of hepatocellular carcinoma in the rat. 14633663 2004