IFNA13, interferon alpha 13, 3447

N. diseases: 646; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE Together this difference in types of T-cell-dependent t1IFN immunity for different <i>Cryptococcus</i> species suggests a possible mechanism by which HIV infection may select against <i>C. gattii</i> but not <i>C. neoformans</i><b>IMPORTANCE</b><i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> cause fatal infection in immunodeficient and immunocompetent individuals. 31213551 2019
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE We also noted that SLAMF7 was sensitive to IFN-⍺ stimulation, a factor elevated during HIV infection. 30530590 2019
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE Up to date only one IFNα subtype (IFNα2) is being used in clinical treatment against chronic virus infections, however its therapeutic success rate is rather limited, especially during Human Immunodeficiency Virus (HIV) infection. 29475588 2018
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE The inclusion criteria for patients were as follows: (1) treatment-naive and treated with PEG IFN-α/RBV, (2) HCV RNA was present in serum for over 6 months before treatment, (3) negative for hepatitis B (HBV) or HIV infection and (4) lacked any other hepatic diseases.All participants in this study were Chinese Han population and infected with HCV genotype 1b and treated with subcutaneous PEG IFN-α at a dose of 180 µg once a week with the addition of 800-1000 mg/d RBV according to weight orally for 48 weeks. 29654010 2018
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE IFN-λ Inhibits Drug-Resistant HIV Infection of Macrophages. 28321215 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE We evaluated the mechanism through which HIV-activated pDCs produce IFN as well as how both monoclonal HIV-specific Abs and Abs produced in natural HIV infection modulated normal pDC sensing of HIV. 29083319 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group BEFREE Vitamin D serum levels and receptor genetic polymorphisms are associated with hepatitis B virus and HIV infections and IFN-λ levels. 29493287 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE In chronic diseases, such as HIV infection, plasmacytoid dendritic cells (pDCs) are rendered dysfunctional, as measured by their decreased capacity to produce IFN-α. 28264968 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group BEFREE HIV infection transiently enhanced the expression of IFNA mRNA. 29252127 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE Using multiple cell systems, including reporter cell lines and activated peripheral blood lymphocytes (PBLs), we show that recombinant IFNɛ impairs HIV infection at stage(s) post HIV entry and up to the translation of viral proteins. 28045025 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE We modeled increased activation in HIV infection by priming human monocytes with IFNα followed by exposure to acetylated LDL (acLDL). 24731171 2014
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE These findings indicate that coinfection is associated with a type 1 IFN monocyte activation profile which was further found to correlate with cognitive impairment, even in subjects with controlled HIV infection. 23437063 2013
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 GeneticVariation group BEFREE Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. 21099665 2011
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group BEFREE Additionally, the response of NK cells to direct IFN-alpha stimulation was defective in viremic HIV infection, and this defect was not attributable to diminished IFN-alpha receptor expression, though IFN-alpha receptor and NKP30 expression was closely associated with killer activity in viremic HIV infection but not in healthy controls. 19692459 2009
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE We developed a real-time PCR assay to simultaneously measure the mRNA level of type I interferon (IFN) receptor (IFNAR) components in peripheral blood cells of children with chronic immune stimulation due to HIV infection. 18338950 2008
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE We have now studied the response of HCV-4 to peg-IFN and ribavirin and investigated the influence of HIV infection on anti-HCV therapy. 16032749 2005
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE Despite the marked reduction of HIV-1 propagation by IFN genes or by negative Tat and Rev transdominants, the gene therapy using soluble CD4 immunoadhesin or anti-gp41 was a more efficient preventive treatment against HIV infection. 14689754 2003
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE Four hypotheses have been presented that suggested that: a) al-IFN-alpha may be a product of a distinct IFN gene; b) or a posttranscriptionally modified IFN-alpha molecule; c) the phenomenon of al-IFN-alpha may be an effect of synergistic action of a mixture of acid-stable IFN-alpha and acid-labile IFN-gamma; d) or the effect may be a result of an interaction of acid-stable IFN-alpha with an unknown factor(s) present in plasma and associated with progression of HIV infection or autoimmune diseases. 10202561 1999