Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lupus and control CD8+ T cells significantly increased STAT1 mRNA levels after treatment with IFNα.
|
30674474 |
2019 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that conventional dendritic cells (cDCs) from predisease lupus-prone B6.NZM Sle1/Sle2/Sle3 triple congenic (TCSle) mice produce more IL-10 than wild-type congenic cDCs upon TLR stimulation, and this overproduction is prevented by blocking the type I IFN receptor (IFNAR) with specific Abs.
|
31216373 |
2019 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
10-week old female lupus-prone (NZM2328), wild-type (BALB/c) and iNZM mice (lack a functional type I IFN receptor on NZM2328 background) were treated on their dorsal skin with 100 mJ/cm<sup>2</sup> of UVB for 5 consecutive days.
|
31248690 |
2019 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus.
|
30745462 |
2019 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Type I IFN and nucleic acid-sensing TLRs are both strongly implicated in the pathogenesis of lupus, with most patients expressing IFN-induced genes in peripheral blood cells and with TLRs promoting type I IFNs and autoreactive B cells.
|
29055005 |
2017 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Murine and human lupus studies revealed a role for IFN-α in vascular abnormalities associated with impaired blood vessel dilation.
|
28779021 |
2017 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because a feedforward loop between the female sex hormone estrogen (E2) and type I interferon (IFN-α/β)-signaling induces the expression of certain p200-family proteins (such as murine p202 and human IFI16) that regulate innate immune responses and modify lupus susceptibility, we investigated whether treatment of myeloid cells with bisphenol A (BPA), an environmental estrogen, could regulate the p200-family proteins and activate innate immune responses.
|
26277401 |
2015 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Persistent production of IFN-α, the most abundant subtype measured in these patients, is an important feature of the immunopathogenesis of lupus and has stimulated current efforts to develop and test therapeutics that either block IFN-I or its receptor directly or target components of the IFN-I pathway involved in induction of or response to IFN-I.
|
25468480 |
2015 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The peptide epitope-induced T cells markedly suppressed type I IFN related gene expression in lupus PBMC.
|
24211843 |
2013 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present studies demonstrate that hCDR1 is also capable of down-regulating significantly (and specifically to lupus) IFN-α gene expression.
|
23555966 |
2013 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice.
|
23175700 |
2012 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given that the expression of some of the p200-family proteins is differentially regulated by sex hormones and these proteins differentially regulate cytosolic DNA-induced production of type I IFN and proinflammatory cytokines (IL-1β and IL-18), the major known contributors of SLE-associated inflammation, we discuss the recent advancements in our understanding of the role of p200-family proteins in lupus susceptibility modification.
|
22841963 |
2012 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
|
22422888 |
2012 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recent data from mouse models of lupus indicate a critical role for IRF5 in the production of pathogenic autoantibodies and the expression of Th2 cytokines and type I IFN.
|
22933628 |
2012 |
Lupus Erythematosus, Discoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Given that the murine lupus susceptibility locus Nba2 includes the IFN-regulated genes Ifi202 (encoding for the p202 protein), Aim2 (encoding for the Aim2 protein), and Fcgr2b (encoding for the FcγRIIB receptor), we investigated whether the IRF5/Blimp-1 axis could regulate the expression of these genes.
|
22116829 |
2012 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The clinical relevance of these findings was verified in a study of 152 lupus patients, in which we showed that lupus nTreg dysfunction is not due to intrinsic defects but is rather induced by C3b stimulation of CD46 and IFN-α and that these immune components of inflammation are directly associated with active lupus.
|
22065791 |
2011 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Compared with controls, the expression of IRF7 mRNA was significantly increased in patients with SLE and was positively correlated with both the serum level of IFN-α and lupus disease activity.
|
21632682 |
2011 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
A genetic setup that promotes type I IFN production and/or response and the presence of endogenous inducers of IFN-α production have been described in patients with lupus.
|
21292501 |
2011 |
Lupus Erythematosus, Discoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Increased production and/or bioavailability of IFN-α and associated alterations in dendritic cell (DC) homeostasis have been linked to lupus pathogenesis.
|
21389264 |
2011 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Produced IFNα may at least partially be responsible for several of the observed alterations in the immune system of lupus patients and contribute to the autoimmune disease process, which will be discussed in the present review.
|
20392290 |
2010 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1β promotes significant improvement in the functional capacity of lupus EPCs/CACs, therefore abrogating the deleterious effects of IFN-α.
|
20805419 |
2010 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that aberrant T cell KIR expression may contribute to IFN overproduction and macrophage killing in human lupus, and they suggest that Abs to inhibitory KIR may be a treatment for this disease.
|
19675166 |
2009 |
Lupus Erythematosus, Discoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
|
17412832 |
2007 |