|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest active tobacco use in HNSCC has an immunosuppressive effect through inhibition of tumor infiltration of cytotoxic T-cells, likely as a result of suppression of IFN response pathways.
|
31848186 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SARI (suppressor of activator protein 1, regulated by IFN) functions as a tumour suppressor and is inactivated in various cancers.
|
30771439 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment of lymphoma-bearing mice with either IFN-DC vaccination or lenalidomide led to a significant decrease in tumor growth and lymphoma cell spread.
|
31620858 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Type I interferons (IFNα and IFNβ) directly regulate transcription of >100 downstream genes, which results in a myriad of direct (on cancer cells) and indirect (through immune effector cells and vasculature) effects on the tumour.
|
30679806 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, to examine the combinatorial effect of IFN-α expression with CCL17 downregulation, IFN-α was transduced into CT26-shCCL17 tumors.
|
30420718 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Functionally, induction of ARG1 limited the therapeutic effect of IFN, as inhibition of arginase activity could strongly synergize with poly(I:C) to enhance CD8<sup>+</sup> T cell responses to thwart tumor growth in mice.
|
30528455 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IFNα, in the body and thus have the ability to influence anti-tumor immune responses.
|
31440253 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, these Tim-3+ NK cells were functionally diverse, as evidenced by the fact that their ability to produce IFN-γ in response to an NK cell responsive tumor was strictly dependent upon the stimuli employed for Tim-3 induction.
|
30876792 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, blocking TGFβ restores the production of IFNα by activated MHCII<sup>+</sup> tumor-associated macrophages, and enables tumor regression induced by STING activation.
|
31511510 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FACS was used to determine the frequencies of Tregs, MDSCs, CD4<sup>+</sup> IFN-γ<sup>+</sup> T cells, and CTLs in the tumors and spleens of the mice. mRNA levels of the transcription factors T-bet and FOXP3 and cytokines IFN-γ, TNF-α, TGF-β, and IL-10 were also determined by real-time RT-PCR.
|
30798159 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Evaluating IFN-related genes from tumor genomic data may aid identification of patients for whom combination therapy including an IFN pathway activator with ICB may be required.<i>This article is highlighted in the In This Issue feature, p. 1143</i>.
|
31217296 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN fusions selectively induced IP-10 secretion from antigen positive tumor cells, which was critical in recruiting the effector T cells to the tumor microenvironment.
|
31393905 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Different Effects of IFN-<i>β</i> and IFN-<i>γ</i> on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells.
|
31149015 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Local administration of IFN-α-producing iPSC-pMCs (IFN-α-iPSC-pMCs) alters the tumor microenvironment and propagates the molecular signature associated with type I IFN.
|
31577946 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we identified the deleterious role of signaling via the type I interferon (IFN) receptor in tumor and antigen presenting cells, that induced the expression of nitric oxide synthase 2 (NOS2), associated with intratumor accumulation of regulatory T cells (Treg) and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody (mAb).
|
31481761 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A significant cytostatic effect of IFNα-2b on the tumor population was detected.
|
30930631 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The PD-1/PD-L1 checkpoint is a central mediator of immunosuppression in the tumor immune microenvironment (TME) and is primarily associated with IFN-g signaling.
|
31730010 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we use human tumor explant cultures and cell culture models to show that the (ds) RNA Sendai Virus (SeV), poly-I:C, and rintatolimod (poly-I:C<sub>12</sub>U) all activate the TLR3 pathway involving TRAF3 and IRF3, and induce IFNα, ISG-60, and CXCL10 to promote CTL chemotaxis to <i>ex vivo</i>-treated tumors.
|
29853604 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The primary endpoint was the association between tumour hMLH1 or/and hMSH2-deficient and VEGF-1 expression; the relation between tumour MMR-status and IFL response rate was the secondary endpoint.
|
30396964 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Most importantly, PSar-IFN is significantly more potent in inhibiting tumor growth and elicits considerably less anti-IFN antibodies in mouse than PEG-IFN.
|
29863329 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our analysis demonstrates that tumors infiltrated by CD8<sup>+</sup> T cells expressing higher levels of activation marker (PD1<sup>hi</sup>) along with TCR signaling genes and cytolytic T cell markers (IL2<sup>hi</sup>/TNF-α<sup>hi</sup>/IFN-γ<sup>hi</sup>/GZMA-B<sup>hi</sup>) extend survival, whereas survival benefit was absent for tumors infiltrated by anergic and hyperexhausted CD8<sup>+</sup> T cells characterized by high expression of <i>CTLA-4, TIM3, LAG3</i>, and genes linked to PI3K signaling pathway.
|
30622534 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The treatment of tumor exosomes drastically decreased CD4<sup>+</sup>IFN-γ<sup>+</sup> Th1 differentiation but increased the rates of regulatory T (Treg) cells.
|
29800589 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Significant lower ratio of CD3<sup>+</sup>CD4<sup>+</sup> T cells and higher ratio of CD8<sup>+</sup>IFN-γ<sup>+</sup> T cells were found in peripheral blood and tumor tissues in miR-570 mimics than NC.
|
29874097 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Elevated IFN-γ within the tumor microenvironment suggests that MS-275 modulates the local cytokine landscape to favor antitumor myeloid polarization through the IFN-γR/STAT1 signaling axis.
|
30021162 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This resulted in markedly fewer TNFR2<sup>+</sup> T<sub>reg</sub> cells and more interferon-γ-positive (IFN-γ<sup>+</sup>) CD8<sup>+</sup> cytotoxic T lymphocytes infiltrating the tumor and improved long-term tumor-free survival in the mouse cohort.
|
29295954 |
2018 |