IFNA13, interferon alpha 13, 3447

N. diseases: 646; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The clinical observation that AA can occur after viral infection or IFN-α administration implies that IFN-α-producing plasmacytoid dendritic cells (pDCs) may be involved in the AA pathogenesis. 31431342 2020
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. 30995506 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Overall, this research on CoBoIFN-ω not only extends and improves consensus IFN research, but also reveals that CoBoIFN-ω has the potential to be used in the therapy of bovine viral diseases. 30576951 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters. 31784575 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection. 31379819 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection. 30195710 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Human UBL4A/GdX, encoding an ubiquitin-like protein, was shown in this study to be upregulated by viral infection and IFN stimulation. 31451677 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Commercially, IFN-α has been approved to treat many chronic viral diseases as well as a variety of cancers and different types of leukemia. 30543053 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE Among the 12 IFNα subtypes, IFNα1 has a uniquely low affinity for IFNAR2 (<100 × of the other IFNα subtypes) and commensurately weak antiviral activity, suggesting an undefined function distinct from suppression of viral infections. 30920934 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Using pharmacological and genetic approaches, we show that lactate reduction by lactate dehydrogenase A (LDHA) inactivation heightens type I IFN production to protect mice from viral infection. 31155231 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE By extension, IFN-αβ or combination therapy may need to be used cautiously to treat viral infections in clinical settings. 31355779 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE IFN responses to viral infection are necessary to establish intrinsic antiviral state, but if unchecked can lead to heightened inflammation. 31548332 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Type I interferon (IFN-I) is critical for antiviral defense, and plasmacytoid dendritic cells (pDCs) are a predominant source of IFN-I during virus infection. pDC-mediated antiviral responses are stimulated upon physical contact with infected cells, during which immunostimulatory viral RNA is transferred to pDCs, leading to IFN production via the nucleic acid sensor TLR7. 31003939 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE IFN α and β are two cytokines, which have a major activity in the innate immune system against viral infections. 30378208 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The interaction of FKBP8 with VISA, retinoic acid inducible protein 1 (RIG-I), and IFN regulatory factor 3 (IRF3) was confirmed during viral infection in mammalian cells by coimmunoprecipitation. 30267576 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE <b>Conclusions:</b> Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants and a subset of children. 30562046 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Infectious bursal disease virus (IBDV) infection triggers the induction of type I IFN, which is mediated by melanoma differentiation-associated protein 5 recognition of the viral genomic double-stranded RNA (dsRNA). 29979632 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE In this review we focus on the role of IFN-λ at barrier surfaces, focusing on the respiratory and GI tracts, the BBB, and the placenta, and on how these IFNs act to suppress viral infections. 30219309 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Interferons (IFNs) are secreted glycoproteins that are produced by cells in response to virus infection and other stimuli and induce an antiviral state in cells bearing IFN receptors. 29551142 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses. 28963109 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE Studies with intramuscular injection of IFN expression plasmids have recently provided surprising results, which may be of relevance for application of IFN-I in prophylaxis against virus infection. 28196779 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Many studies have investigated the pathways involved in the induction of IFN-α/β after virus infection and the resultant upregulation of antiviral IFN-stimulated genes (ISGs) through IFN-α/β receptor complex signaling. 29691338 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE We found that following an IFN-inducing stimulus such as viral infection or polyI:C, programmed cell death ligand 1 (PD-L1) expression is dynamically upregulated on lymphatic endothelial cells (LECs). 30045970 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE SAMHD1 has been suggested to down-regulate IFN and inflammatory responses to viral infections, although the functions and mechanisms of SAMHD1 in modulating innate immunity remain unclear. 29610295 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE Correction: IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection. 29342220 2018