Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The clinical observation that AA can occur after viral infection or IFN-α administration implies that IFN-α-producing plasmacytoid dendritic cells (pDCs) may be involved in the AA pathogenesis.
|
31431342 |
2020 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs.
|
30995506 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, this research on CoBoIFN-ω not only extends and improves consensus IFN research, but also reveals that CoBoIFN-ω has the potential to be used in the therapy of bovine viral diseases.
|
30576951 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters.
|
31784575 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection.
|
31379819 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection.
|
30195710 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Human UBL4A/GdX, encoding an ubiquitin-like protein, was shown in this study to be upregulated by viral infection and IFN stimulation.
|
31451677 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Commercially, IFN-α has been approved to treat many chronic viral diseases as well as a variety of cancers and different types of leukemia.
|
30543053 |
2019 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among the 12 IFNα subtypes, IFNα1 has a uniquely low affinity for IFNAR2 (<100 × of the other IFNα subtypes) and commensurately weak antiviral activity, suggesting an undefined function distinct from suppression of viral infections.
|
30920934 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Using pharmacological and genetic approaches, we show that lactate reduction by lactate dehydrogenase A (LDHA) inactivation heightens type I IFN production to protect mice from viral infection.
|
31155231 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
By extension, IFN-αβ or combination therapy may need to be used cautiously to treat viral infections in clinical settings.
|
31355779 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN responses to viral infection are necessary to establish intrinsic antiviral state, but if unchecked can lead to heightened inflammation.
|
31548332 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferon (IFN-I) is critical for antiviral defense, and plasmacytoid dendritic cells (pDCs) are a predominant source of IFN-I during virus infection. pDC-mediated antiviral responses are stimulated upon physical contact with infected cells, during which immunostimulatory viral RNA is transferred to pDCs, leading to IFN production via the nucleic acid sensor TLR7.
|
31003939 |
2019 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IFN α and β are two cytokines, which have a major activity in the innate immune system against viral infections.
|
30378208 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The interaction of FKBP8 with VISA, retinoic acid inducible protein 1 (RIG-I), and IFN regulatory factor 3 (IRF3) was confirmed during viral infection in mammalian cells by coimmunoprecipitation.
|
30267576 |
2019 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
<b>Conclusions:</b> Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants and a subset of children.
|
30562046 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Infectious bursal disease virus (IBDV) infection triggers the induction of type I IFN, which is mediated by melanoma differentiation-associated protein 5 recognition of the viral genomic double-stranded RNA (dsRNA).
|
29979632 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review we focus on the role of IFN-λ at barrier surfaces, focusing on the respiratory and GI tracts, the BBB, and the placenta, and on how these IFNs act to suppress viral infections.
|
30219309 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferons (IFNs) are secreted glycoproteins that are produced by cells in response to virus infection and other stimuli and induce an antiviral state in cells bearing IFN receptors.
|
29551142 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses.
|
28963109 |
2018 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Studies with intramuscular injection of IFN expression plasmids have recently provided surprising results, which may be of relevance for application of IFN-I in prophylaxis against virus infection.
|
28196779 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Many studies have investigated the pathways involved in the induction of IFN-α/β after virus infection and the resultant upregulation of antiviral IFN-stimulated genes (ISGs) through IFN-α/β receptor complex signaling.
|
29691338 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that following an IFN-inducing stimulus such as viral infection or polyI:C, programmed cell death ligand 1 (PD-L1) expression is dynamically upregulated on lymphatic endothelial cells (LECs).
|
30045970 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
SAMHD1 has been suggested to down-regulate IFN and inflammatory responses to viral infections, although the functions and mechanisms of SAMHD1 in modulating innate immunity remain unclear.
|
29610295 |
2018 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Correction: IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection.
|
29342220 |
2018 |