|
Rhinovirus infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In adjusted analysis, rhinovirus C infections were associated with increased IFN-α (<i>P</i> = 0.045) and decreased RORC2 expression (<i>P</i> = 0.025).
|
31827765 |
2019 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pretreatment with quercetin, which increases SIRT-1 expression, normalized RV-induced IFN levels in COPD airway epithelial cells.
|
31548332 |
2019 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lower epithelial IFN-α/β expression was related to greater viral load, worse airway symptoms, airway hyperresponsiveness, and reductions in lung function during rhinovirus infection.
|
29698627 |
2019 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Anti-IL-33 decreased rhinovirus replication and increased IFN-λ levels at the gene and protein levels.
|
28947081 |
2018 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Multiple lines of evidence support an association between higher ORMDL3 and increased rhinovirus-induced HSPA5 and type I IFN gene expression.
|
28192616 |
2017 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, during symptomatic visits because of disease exacerbation associated with RV detection in NPF, IFN-α production was found increased, while IFN-λ secretion was already induced by RV in asthmatic children at baseline.During asthma exacerbations associated with RV, asthmatic children can induce IFN-α secretion, indicating a hyperactive immune response to repeated respiratory virus infection.
|
27836955 |
2017 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, these studies suggest that increased levels of ORMDL3 contribute to antiviral defense to RV infection in mice through pathways that may include IFNs (IFN-α, IFN-β, IFN-λ), OAS, and RNAse L.
|
28827284 |
2017 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).
|
28373098 |
2017 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
To gain insight into IFN-independent mechanisms limiting RV replication at 37 °C, we studied RV infection in human bronchial epithelial cells and H1-HeLa cells.
|
27402752 |
2016 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In airway epithelial cells, blocking TLR2 enhanced RV-induced expression of IFNs and CXCL-10.
|
27503209 |
2016 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, defective IFN-λ production by humans with asthma impairs the control of rhinovirus infection.
|
24329419 |
2014 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some investigators find a deficiency in IFN production from airway epithelial cells infected with human rhinovirus in asthma, but whether this abnormality occurs with other respiratory viruses is uncertain.
|
25216987 |
2014 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, total serum IgE levels correlated negatively with rhinovirus-induced IFN-λ mRNA levels (P < .05 and r = -0.41) and positively with rhinovirus viral RNA levels (P < .05 and r = 0.44).
|
22981791 |
2012 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rhinovirus 16-induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients.
|
22657407 |
2012 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice inoculated with vMC(0), compared with those inoculated with vehicle or UV-inactivated vMC(0), exhibited increased pulmonary expression of interferon (IFN-α, IFN-β, IFN-λ), viral RNA sensors [toll-like receptor (TLR)3, TLR7, nucleotide-binding oligomerization domain containing 2 (NOD2)], and chemokines associated with HRV infection in humans (CXCL10, CCL2).
|
22355409 |
2012 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Airway epithelial cells from patients with COPD show higher baseline levels of cytokine expression and increased susceptibility to RV infection, despite an increased IFN response.
|
20395558 |
2010 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways.
|
16210696 |
2006 |