|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that macrophage TBK1 contributes to both IFN and non-IFN components of host defense and IAV pathology.
|
30290124 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Type III interferon (IFN-λ) is important for innate immune protection at mucosal surfaces and has therapeutic benefit against influenza A virus (IAV) infection.
|
31235953 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The AnxA1-mediated protection against IAV infection was not caused by priming of the type I IFN response but was associated with an increase in the number of alveolar macrophages (AMs) and enhanced pulmonary expression of the AM-regulating cytokine granulocyte-M-CSF (GM-CSF).
|
31398292 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of cytokines, including TNF-α, IL-6, IL-10, and type I IFN (IFN-α and IFN-β), in bronchoalveolar lavage fluid (BALF) were altered after IAV infection; in particular, IFN-α and IFN-β levels were significantly suppressed in the BALF of DIO mice.
|
30967261 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
IFN-Alpha1 antisense RNA represses human influenza A virus growth in a guinea pig system.
|
30844714 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
IFN and cytokine responses in ducks to genetically similar H5N1 influenza A viruses of varying pathogenicity.
|
29458524 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
IFN-λ and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs.
|
29677213 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrate the role of IFN regulatory factor (IRF)1 in promoting NLRP3 inflammasome activation and cell death during IAV infection.
|
29321274 |
2018 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-λ expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-λ expression.
|
30224514 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential Induction of IFN-α and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-γ Response to Influenza A Viruses.
|
30143589 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we studied the IFN-regulated innate immune response against influenza A virus (IAV) infection in the mouse lung and the therapeutic effect of IFN-λ2/3 in acute IAV lung infection.
|
27632156 |
2017 |
|
Influenza A
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast, robust tetherin induction was observed by infection of rPIV-2s carrying V mutants, in which either three Trp residues (W178H/W182E/W192A) or Cys residues (C209/211/214A) that are important for decreasing cell surface tetherin are mutated. hPIV-2 infection also inhibited the induction of tetherin expression by IFN-α and IAV infection.
|
28455649 |
2017 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Through interacting with TANK-binding kinase 1, HERP amplifies the MAVS signaling and facilitates the phosphorylation and nuclear translocation of IFN regulatory factor 3 and NF-κB to enhance the expression of IFNs, which leads to a broad inhibition of the replication of RNA viruses, including EV71, Sendai virus, influenza A virus, and vesicular stomatitis virus.
|
28954889 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, data from animal models show that IFN-λ contributes to host control of viruses infecting these sites, including influenza A virus, severe acute respiratory syndrome coronavirus, and rotavirus.
|
24329419 |
2014 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At high viral doses, IFN-α levels reached by some mammalian IAV surpassed those induced by avian isolates.
|
21994734 |
2011 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicate a novel mechanism by which influenza A-induced type I IFNs inhibit Th17 immunity and increase susceptibility to secondary bacterial pneumonia.
|
21178015 |
2011 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ubiquitin-like protein ISG15, which is robustly induced by IFN or virus, is implicated to inhibit influenza A virus (IAV) in vivo.
|
20385878 |
2010 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The DeltaNS1-B vaccine candidate was attenuated in IFN-competent hosts such as human alveolar epithelial cells (A549) similar to influenza A DeltaNS1 viruses.
|
19366569 |
2009 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The latter is not due to a general defect in IFN signaling, as IFN-gamma induces the nuclear translocation of signal transducer and activator of transcription 1 (STAT1), the enhanced transcription of several IFN-regulated genes, and the inhibition of unrelated viruses such as influenza A virus and Semliki Forest virus.
|
16227297 |
2005 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, IFN produced in response to influenza A or vaccinia virus (VV) was a mixture of usually more than 80% IFN-alpha and up to 20% IFN-beta.
|
15035851 |
2004 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, the influenza A virus NS1 protein was shown to be a type I IFN antagonist that plays an important role in viral pathogenesis.
|
11226311 |
2001 |