APOC3, apolipoprotein C3, 345

N. diseases: 153; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 AlteredExpression disease BEFREE The development of hyperlipidemia in acne patients treated with retinoic acid (RA) has been attributed to the induction of apolipoprotein C-III expression. 24234421 2014
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 Biomarker disease BEFREE Experimental therapies targeting apolipoprotein C-III for the treatment of hyperlipidemia - spotlight on volanesorsen. 30753100 2019
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 GeneticVariation disease BEFREE Patients with the APOC3 3238 G>C/APOA5 -1131 T>C polymorphism showed a more severe hyperlipidemia than patients without this polymorphism. 19034316 2009
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 Biomarker disease BEFREE In summary, we have successfully generated a novel hypertriglyceridemic ApoCIII transgenic miniature pig model that could be of great value for studies on hyperlipidemia in relation to atherosclerotic disorders. 22023023 2012
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 Biomarker disease HPO
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 GeneticVariation disease BEFREE We have studied the frequency of DNA polymorphisms in and around the apolipoprotein A-1 (Apo-A1) and apolipoprotein CIII (Apo-CIII) gene loci in 53 persons of Caucasian descent with genetic hyperlipidemias. 2883893 1987
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 Biomarker disease BEFREE Thus, Apoc3 deficiency can prevent apoE-induced hyperlipidemia associated with a 10-fold increased hepatic VLDL-TG production rate, most likely by alleviating the apoE-induced inhibition of VLDL-TG hydrolysis. 15863838 2005
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 Biomarker disease BEFREE APOC3 is an important molecule in lipid metabolism that is closely associated with hyperlipidemia and an increased risk of developing CVD. 27619170 2016
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 GeneticVariation disease BEFREE When stratifying by hyperlipidemia, CAD patients with hyperlipidemia had a significantly higher frequency of APOC3 3238 GG genotype (OR =1.73, 95% CI =1.13, 2.64; P = 0.01) than without hyperlipidemia. 25380998 2014
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 GeneticVariation disease BEFREE To describe some steps in the progress in the molecular biology of a peptide, apolipoprotein C3; its gene mutations that render individuals susceptible or resistant to developing hyperlipidaemia and atherosclerosis. 28441154 2017
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 GeneticVariation disease LHGDN Apolipoprotein C-III and E polymorphisms and cardiovascular syndrome, hyperlipidemia, and insulin resistance in renal transplantation. 12118856 2002