Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Apolipoprotein C-III gene variation and dyslipidaemia.
|
9211063 |
1997 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Therefore, although the individual risk of hypertriglyceridemia is increased in women with the haplotype T, C at -482, -455, it appears that the -482, -455 and SstI APOC-III gene polymorphisms are not major contributors to the risk of dyslipidemia in the population of northern France.
|
10781646 |
2000 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We evaluated the contribution of APOC3 -482C-->T, -455T-->C, and 3238C-->G; epsilon 2 and epsilon 4 alleles of APOE; and TNF -238G-->A to dyslipidemia and lipoatrophy by longitudinally modeling >2600 lipid determinations and 2328 lipoatrophy assessments in 329 ART-treated patients during a median follow-up period of 3.4 years.
|
15809899 |
2005 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in the fatty acid-binding protein 2 and apolipoprotein C-III genes are associated with the metabolic syndrome and dyslipidemia in a South Indian population.
|
15598690 |
2005 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in the fatty acid-binding protein 2 and apolipoprotein C-III genes are associated with the metabolic syndrome and dyslipidemia in a South Indian population.
|
15598690 |
2005 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Apolipoprotein C-III (apoC-III) gene variants, which vary by race/ethnicity, have been associated with a lipid profile that resembles PI-induced dyslipidemia.
|
16417409 |
2006 |
Dyslipidemias
|
0.100 |
AlteredExpression
|
group |
LHGDN |
To evaluate the influence of cholesterol ester transfer protein (CETP) TaqIB polymorphism, lipoprotein lipase (LPL) PvuII and HindIII polymorphisms, hepatic lipase (LIPC) G-250A polymorphism and apolipoprotein C-III (APOC3) SstI gene polymorphism on lipid levels in dyslipidemia of the metabolic syndrome, 150 patients with dyslipidemia of metabolic syndrome were included.96 % of patients had type 2 diabetes.
|
16343038 |
2006 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To evaluate the influence of cholesterol ester transfer protein (CETP) TaqIB polymorphism, lipoprotein lipase (LPL) PvuII and HindIII polymorphisms, hepatic lipase (LIPC) G-250A polymorphism and apolipoprotein C-III (APOC3) SstI gene polymorphism on lipid levels in dyslipidemia of the metabolic syndrome, 150 patients with dyslipidemia of metabolic syndrome were included.96 % of patients had type 2 diabetes.
|
16343038 |
2006 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The contribution to dyslipidemia of 20 selected single nucleotide polymorphisms of 13 genes reported in the literature to be associated with plasma lipid levels (ABCA1, ADRB2, APOA5, APOC3, APOE, CETP, LIPC, LIPG, LPL, MDR1, MTP, SCARB1, and TNF) was assessed by longitudinally modeling more than 4400 plasma lipid determinations in 438 antiretroviral therapy-treated participants during a median period of 4.8 years.
|
17700364 |
2007 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
APOC3 polymorphisms might be associated with both dyslipidemia and lipoatrophy in HAART-treated patients.
|
18240956 |
2008 |
Dyslipidemias
|
0.100 |
Biomarker
|
group |
LHGDN |
Apolipoprotein CIII links hyperlipidemia with vascular endothelial cell dysfunction.
|
18663085 |
2008 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Antiretroviral treatment-induced dyslipidemia in HIV-infected patients is influenced by the APOC3-related rs10892151 polymorphism.
|
21939545 |
2011 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The T-455C and C-482T APOC3 promoter region polymorphisms (SNPs) have recently been reported to predispose to dyslipidemia, insulin resistance, and nonalcoholic fatty liver disease (NAFLD) in Indian subjects, but the association with liver damage has not been evaluated so far.
|
21777557 |
2011 |
Dyslipidemias
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We sought to identify single nucleotide polymorphisms (SNPs) associated with apoC-III level response to combination therapy with statins and fenofibric acid (FA) in individuals with mixed dyslipidemia.
|
22236405 |
2012 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In individuals with mixed dyslipidemia rare synonymous variants within LPL gene were associated with attenuated response to FA therapy while APOCIII rare variants were associated with a modest effect on APOB response to FA-statin therapy.
|
24704626 |
2014 |
Dyslipidemias
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The aim of the study was to scrutinize the effect of Clematichinenoside (AR) on dyslipidemia-induced atherosclerosis and explore its capability on expression of Peroxisome proliferator-activated receptor-α (PPAR-alpha), apolipoprotein A-I (APOA1) and A-II (APOA2), and suppression of apolipoprotein C-III (APOC3) genes and proteins.
|
25979856 |
2015 |
Dyslipidemias
|
0.100 |
Biomarker
|
group |
BEFREE |
Complex metabolic disorders of apolipoproteins are present in T2DM, such as high plasma apoB, apoC‑II, apoC‑III and apoE concentrations, and low plasma apoA‑I and apoM concentrations, which are associated with dyslipidaemia and interrelated complications.
|
29152661 |
2017 |
Dyslipidemias
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we focus on dyslipidemia drug targets traceable to human genetic studies, including statins and ezetimibe, as well as promising new classes such as inhibitors of proprotein convertase subtilisin kexin 9, apolipoprotein B, microsomal triglyceride transfer protein, cholesteryl ester transfer protein, angiopoietin-like proteins types 3 and 4 and apolipoprotein C-III.
|
28109622 |
2017 |
Dyslipidemias
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Particularly, the variants rs632153, rs633389, rs2187126 and rs1263163 might be risk conferring to dyslipidemia by elevating LDLC and TC levels, while the variants of APOC3 and APOA1 genes might be the genetic determinants of elevated triglycerides in the present population.
|
28610615 |
2017 |
Dyslipidemias
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Plasma levels of PCSK9, apoC3, and sdLDL-C were associated with the current dyslipidemias classification (all p<0.001).
|
27713142 |
2017 |
Dyslipidemias
|
0.100 |
Biomarker
|
group |
BEFREE |
These apoC-III beneficial modifications may have implications in dyslipidemia improvement and contribute to cardiovascular risk reduction after surgery.
|
28502507 |
2018 |
Dyslipidemias
|
0.100 |
Biomarker
|
group |
BEFREE |
We discuss APOC3-targeted experimental treatments for dyslipidemia.
|
30753100 |
2019 |
Dyslipidemias
|
0.100 |
Biomarker
|
group |
BEFREE |
To illustrate the importance of intact proteoform testing with MS and its potential clinical implications, we discuss here recent findings from multiple studies on the distribution of apolipoprotein C-III proteoforms and their correlations with key clinical measures of dyslipidemia.
|
31834860 |
2019 |
Dyslipidemias
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, RNA interference of apoCIII prevents fructose-induced dyslipidemia in nonhuman primates.
|
31789670 |
2020 |