|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Results Variant genotypes of polymorphisms -863 C > A and -1031 T > C of the TNFA gene, 455 T > C of the APOC3 gene and the wild type of +276 G > T of the ADIPOQ gene were associated with obesity with odds ratios (OR, 95% confidence interval [CI]) of 2.5 (1.5-4.4), 2.5 (1.5-4.2), 2.0 (1.1-3.6) and 2.5 (1.4-5.0), respectively.
|
31216264 |
2019 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The APOC3 rs2070666 A allele is a risk factor for NAFLD independent of obesity, dyslipidemia, and PNPLA3 rs738409, and it might contribute to increased liver fat content in Chinese Han population.
|
27059980 |
2016 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
No association was found between the APOC3 (-455T>C) polymorphism and obesity, impaired glucose tolerance, hyperuricemia, hypercholesterolemia, or high levels of low-density lipoprotein cholesterol (LDL) (P > 0.05).
|
25320541 |
2014 |
|
Obesity
|
0.080 |
Biomarker
|
disease |
BEFREE |
APOC3 -482TT genotype is associated with high apoC-III concentrations only in the presence of abdominal obesity or insulin resistance, but not in current smokers who remain lean or insulin-sensitive.
|
21185820 |
2011 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate such association between the APOC3 -482C>T polymorphism and cardiometabolic risk factors in the turkish adult risk factor (TARF) study cohort, stratifying by gender and obesity.
|
22004016 |
2011 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The odds ratios for MI for the APOC3*222 haplotype were 1.72 (95% CI: 1.16, 2.54) and 1.84 (1.31, 2.59) in subjects in the lowest quintiles of abdominal obesity and fasting hyperglycemia, respectively, and were 0.75 (0.54, 1.05) and 1.16 (0.85, 1.59) in subjects in the highest quintiles, respectively (P for interaction <0.05).
|
18541587 |
2008 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In multivariate regression models, the c56C > G SNP, plasma apoCIII, plasma nonesterified fatty acids, hepatic APOA5 transcripts, sex and a weak association with obesity status explained 61% of the variance in apoAV plasma levels.
|
18537870 |
2008 |
|
Obesity
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Multivariable logistic regression analysis with adjustment for age, sex, and the prevalence of smoking revealed that the -30Gright curved arrow A polymorphism of GCK, the -240Aright curved arrow T polymorphism of ACE, and the -482Cright curved arrow T polymorphism of APOC3 were significantly (P < 0.01) associated with the prevalence of obesity, and the -1989Tright curved arrow G polymorphism of ESR1 was almost significantly associated.
|
17016614 |
2006 |