|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression.
|
18614013 |
2008 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interferon-β modulates type 1 immunity during influenza virus infection.
|
20659503 |
2010 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IFN-β mRNA expression was quantified by real-time PCR (RT-PCR), and IRF-3 activity was measured by the levels of IRF-3 dimerization and phosphorylation, induced by NDV infection or polyriboinosinic:polyribocytidylic acid [poly(I:C)].
|
23122814 |
2012 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interferon-beta (IFN-beta) gene is transcriptionally activated following virus infection of various cell types such as fibroblasts.
|
2566973 |
1989 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-β is a key component of the innate immune response to viral infection.
|
31461630 |
2020 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Additionally, this study clarifies aspects of the dynamic changes that occur with the nucleosome occupying the transcriptional start site of the interferon beta gene after virus infection.
|
24673249 |
2014 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
After stimulation with polyinosinic-polycytidylic acid (poly I:C) (0.25 μg/ml) for 4 h to mimic viral infection, 293FT wild-type (WT) and IRF7-Δ7 cells were treated with 0, 1, or 100 μM nicotine for 24 h, which increased IFN-β expression in both types of cells but elevation was higher in WT cells (p < 0.001).
|
31154625 |
2019 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Beta interferon (IFN-beta) gene expression in response to virus infection relies on the dynamic assembly of a multiprotein enhanceosome complex that is initiated by the activation of two inducible transcription factors, interferon regulatory factor 3 (IRF3) and NF-kappaB.
|
16581785 |
2006 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both H9N2 virus infection and viral particle inoculation increased the expression of IFITM1 without elevating the levels of interferon-ɑ/β in HUVECs.
|
29100522 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cardiac myocytes express high basal levels of IFN-β to help pre-arm them against viral infections, however the mechanism underlying this expression remains unclear.
|
28822807 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Consistently, knockdown of RNF26 inhibited the expression of IFNB1 gene in various cells at the early phase and promoted it at the late phase of viral infection, respectively.
|
25254379 |
2014 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Development of reporter systems for in vivo examination of IFN-β induction or signaling of type I interferon (IFN-I) pathways is of great interest in order to characterize biological responses to different inducers such as viral infections.
|
27007218 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Disruption of the gene encoding ZAPS resulted in impaired induction of interferon-α (IFN-α), IFN-β and other cytokines after viral infection.
|
21102435 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Efficient induction of IFN-beta requires virus infection and LT signaling, demonstrating the need for both host and viral factors in the curtailment of viral replication without cellular elimination.
|
11672543 |
2001 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, an intact ubiquitin binding domain of ABIN1 was essential for ABIN1 to interact with TBK1/IKKi and inhibit IFN-β production upon poly(I:C) transfection or virus infection.
|
21885437 |
2011 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, we showed that STAU1 and VP3 suppressed IFN-β gene transcription in response to IBDV infection in an additive manner.
|
29979632 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
For example, small RNA cleavage products produced by RNase L during viral infections can signal to the retinoic acid-inducible-I like receptors to amplify and perpetuate signaling to the IFN-β gene.
|
21190483 |
2011 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further results revealed that KBD elevated the protein expression of MAVS, which subsequently increased the IFN-β and IFITM3 protein levels, thereby helping to fight viral infections.
|
28314479 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, RelAp43 stimulates the expression of HIAP1, IRF1, and IFN-β - three genes involved in cell immunity against viral infection.
|
23271966 |
2012 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we found that ML323, a specific USP1-UAF1 inhibitor, attenuated IFN-β expression and enhanced viral replication both in vitro and in vivo<i>.</i> Therefore, our results outline a novel mechanism for the control of TBK1 activity and suggest USP1-UAF1 complex as a potential target for the prevention of viral diseases.
|
29138248 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we show that secretion of WNT2B and WNT9B and stabilization of β-catenin (CTNNB1) upon virus infection negatively regulate expression of representative inducible genes IFNB1, IFIT1 and TNF in a CTNNB1-dependent effector mechanism.
|
23785285 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we find that the DNA demethylase TET3 is a negative regulator of IFN-β in response to poly(I:C) stimulation or viral infection.
|
27425624 |
2016 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we found that H3K79me2/3 modification levels at the Il6 and Ifnb1 promoters, as well as H3K79me2 modification at the Tnfα promoter, were increased in macrophages activated by Toll-like receptor (TLR) ligands or virus infection.
|
30275539 |
2020 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we identified metabolite-sensing GPCR TGR5 as an interferon (IFN)-stimulated gene (ISG) which had increased expression following viral infection or IFN-β stimulation in a STAT1-dependent manner.
|
30333836 |
2018 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, precise quantification of low IFN-beta mRNA concentrations, which is advantageous for investigating IFN-beta gene expression in small tissue samples or during the early stage of a virus infection, remains a challenge.
|
14596815 |
2003 |