Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Long-term follow-up studies of DMTs in MS have generally shown that the short-term effects in clinical trials are maintained for up to 21 years, e.g. in the case of interferon beta-1b.
|
30610426 |
2020 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Fingolimod in paediatric MS was associated with consistent control of disease activity versus IFN β-1a (including treatment-naïve and younger patients) and resulted in less disability progression for up to 2 years.
|
31467033 |
2020 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fourteen percent of all patients were treated with chronic immunosuppressants, 38% of patients with NMO underwent plasmapheresis, and 50% of patients with MS were treated with interferon-β.
|
31732227 |
2020 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interferon-beta (IFN-β) has emerged as one of the most common drugs for the treatment of RR-MS patients.
|
31606972 |
2020 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Episodic relapses of the disease which lead to brain lesions and irreversible neurological dysfunctions could be decreased by the interferon-beta (IFN-β) therapy in most of the MS patients.
|
31649263 |
2020 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the prognostic value of select clinical scores in interferon beta-1b (IFNβ-1b) treated MS patients.
|
31793659 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interferonbeta-1b (IFNβ-1b) developed as therapeutic protein for the treatment of multiple sclerosis (MS).
|
31522451 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The objective of our study was to evaluate the relationship of percentage of annualized brain volume loss (aBVL) and no evidence of disease activity (NEDA) in multiple sclerosis (MS) patients under interferon beta 1-a subcutaneous treatment (IFN-beta) during 3 years of follow up.
|
30401571 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed at investigating whether switching to intramuscular IFNB-1a injected once/week with the Avonex®Pen™ device improves treatment tolerability and quality of life in stable MS patients.
|
30763907 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recombinant human interferon beta (rIFN-β) has long been used as a first-line treatment for multiple sclerosis (MS), and any attempt to develop a long-acting rIFN-β is desirable since only one pegylated version of long-acting rIFN-β-1a (Plegridy) is currently available in clinics.
|
30684504 |
2019 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GA reduces multiple sclerosis (MS) disease activity and has shown comparable efficacy with high-dose interferon-β.
|
29440323 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Three randomized trials (CAMMS223, Comparison of Alemtuzumab and Rebif Efficacy in Multiple Sclerosis (CARE-MS) I, and CARE-MS II) compared two courses of alemtuzumab 12 mg with SC IFNB-1a 44 μg in patients with active relapsing-remitting MS. An extension study (CAMMS03409) provided further evaluation and as-needed alemtuzumab retreatment.
|
30289355 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The immune regulatory properties of type I IFNs have led to the approval of IFN-β for the treatment of relapsing-remitting MS.
|
31209101 |
2019 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The authors aim to understand how lymphocyte populations could predict the course of multiple sclerosis (MS) in people treated with interferon-β (IFN-β).
|
30592627 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interferon beta (IFNβ) is an approved treatment for relapsing-remitting and secondary progressive MS.
|
30692524 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The crude rate of infections was higher in patients with MS taking interferon beta and GA than the general population (incidence rate, 8.9 [95% CI, 6.4-12.1] vs 5.2 [95% CI, 4.8-5.5] per 1000 person-years), and higher still in patients taking fingolimod (incidence rate, 14.3 [95% CI, 10.8-18.5] per 1000 person-years), natalizumab (incidence rate, 11.4 [95% CI, 8.3-15.3] per 1000 person-years), and rituximab (incidence rate, 19.7 [95% CI, 16.4-23.5] per 1000 person-years).
|
31589278 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Combination therapy with interferon beta-1a and sesame oil in multiple sclerosis.
|
31331574 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Injection site reactions (ISRs) and influenza-like illness are the most common adverse effects of interferon beta therapies and can present a burden for MS patients leading to non-adherence and discontinuation of therapy.
|
31202258 |
2019 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results showed that IFN-β can reduce the proportion of Th17 cells, the levels of IL-17 and IL-23 in serum of MS.
|
31517556 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we present new evidence supporting the importance of rare genetic variation in the inflammasome signaling pathway and its regulation via autophagy and interferon-β to the etiology of MS.
|
31235738 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
To assess the impact of including future price reductions following LOE on the cost-effectiveness of fingolimod versus intramuscularly administered interferon beta-1a (IM IFNβ-1a) as treatments for multiple sclerosis.
|
30917079 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The oldest and most frequently used medication for MS is interferon beta, either used alone or as add-on therapy with other drugs.
|
31565644 |
2019 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The modern era of multiple sclerosis (MS) treatment began 25 years ago, with the approval of IFNβ and glatiramer acetate for the treatment of relapsing-remitting MS.
|
30315270 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interferon beta-1b was the first drug to be approved in the 1990s for relapsing-remitting MS to modulate the course of the disease.
|
31354720 |
2019 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Development of autoimmune hepatitis (AIH) has been sporadically reported in patients with multiple sclerosis (MS) either concurrently or after treatment with immunomodulatory drugs, including interferon-beta (IFN-β) and steroids.
|
30594597 |
2019 |