Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD.
|
31654602 |
2020 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
IRGM is an established genetic risk factor for Crohn disease (CD) and several other inflammatory disorders.
|
31177914 |
2019 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
SNPs rs72553867 (IRGM gene), rs4409764 (NKX2-3 gene), and rs3731772 (AOX1 gene) increase the risk of pCD.
|
31844038 |
2019 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
By suppressing inflammasome activation, IRGM/Irgm1 protects from pyroptosis and gut inflammation in a Crohn's disease experimental mouse model.
|
30612879 |
2019 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here we report an integrative analysis of an expanded number of Crohn's disease (CD) related genetic defects in innate immune function (NOD2, ATG16L1, IRGM, CARD9, XBP1, ORMDL3) and composition of the ileal microbiome by combining the initial patient cohort (Batch 1, 2005-2010, n = 165) with a second consecutive patient cohort (Batch 2, 2010-2012, n = 118).
|
30818349 |
2019 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggest that genetically encoded IRGM deficiency may predispose to CD through dysregulation of inflammatory gene networks.
|
30335469 |
2019 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The rs4958843 in IRGM promoter is associated with tuberculosis and Crohn's disease.
|
29178192 |
2018 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
None of the so-called predisposing alleles of IRGM gene predispose Iranians to Crohn's disease while the prevalence of some of them like CNV deletion was higher in normal controls.
|
29960072 |
2018 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
IRGM regulates necroptosis and release of DAMPs to induce gastrointestinal inflammation, linking IRGM activity with CD.
|
29274870 |
2018 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to characterize the relationship between VAT, IRGM gene variants, and NAFLD risk in patients with CD.
|
29788077 |
2018 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Immunity-related GTPase M (<i>IRGM</i>) is an established risk allele in CD.
|
29361512 |
2018 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Impaired Paneth cell expression of antimicrobial protein (AMP) lysozyme is found in patients with Crohn's disease with the autophagy gene ATG16L1 risk allele, in mice with mutations in autophagy genes Atg16L1, Atg5 and Atg7, and in Irgm1 knockout mice.
|
28770667 |
2017 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.Nat.Gen. 39: (7), 830-832.), and show that the estimated ORs can vary substantially if both selection and correlation are taken into account.
|
26993061 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
For CD patients, laboratory data were correlated with clinical phenotype, use of immunomodulation, and CD risk alleles (NOD2, IL-23R, ATG16L1 and IRGM).
|
25809337 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that IRGM variants may modulate clinical characteristics of Crohn's disease.
|
26066377 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
IRGM rs72553867 exhibited association with CD with respect to its minor allele frequency (OR 0.50, 95% CI 0.27-0.91, P = 0.02) and genotype distribution (dominant model: OR 0.50, 95% CI 0.23-0.94, P = 0.03).
|
25944217 |
2015 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genotyping for ATG16L1, NOD2/CARD15, and IRGM1 was performed in 80 consecutive patients with Crohn's disease (median age: 11 years; range: 0.7-17.9 years).
|
24656308 |
2014 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The IRGM gene was amplified in four segments and Sanger-sequenced in 101 participants (42 Crohn's disease, 39 ulcerative colitis, and 20 healthy controls).
|
25191865 |
2014 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Thus, the IRGM rs13361189 polymorphism is promising as a biomarker for early diagnosis of CD.
|
25526194 |
2014 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this review, we summarize recent studies on the CD-associated NOD2, ATG16L1 and IRGM risk variants and their contribution to the autophagy functions that have most influenced our understanding of CD pathophysiology.
|
23328432 |
2013 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There is a significant association of CD with the single nucleotide polymorphisms (SNPs) in ATG16L1 (odds ratio [OR] 1.36 [1.15-1.60], P = 2.7 × 10(-6) for allele G), IRGM (OR 1.56 [1.21-1.93], P = 3.9 × 10(-4) for allele C), and ITLN1 (OR 1.55 [1.28-1.88], P = 4.9 × 10(-4) for allele C).
|
22573572 |
2013 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Genetic variations involved in the innate immune system (NOD2, ATG16L1, and IRGM) showed no association with CD susceptibility in the Japanese population.
|
23388546 |
2013 |