|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that MtbDNA induced phenotypical changes, the significant production of TNF-α, and autophagy confirmed by the augmented expression of immunity related GTPase M (IRGM) and autophagy related ATG16L1 genes in M1 macrophages, whereas M2 macrophages exhibited limited responses.
|
31054870 |
2019 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs4958843 in IRGM promoter is associated with tuberculosis and Crohn's disease.
|
29178192 |
2018 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis showed that IRGM rs10065172 and rs4859846 were significantly associated with tuberculosis risk in all genetic models whereas the latent tuberculosis infection group in 1 study was excluded.
|
29068986 |
2017 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, IRGM polymorphism differences between latent and active TB suggests that genetic differences in autophagy might partly affect host TB infection status.
|
26980495 |
2016 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human immunity-related GTPase M (IRGM) is found to play an important role in defense against intracellular pathogen Mycobacterium tuberculosis (M. tuberculosis) in vitro by regulating autophagy.
|
26786655 |
2016 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that IRGM genetic variants could be associated with susceptibility to active TB disease in the Korean population.
|
24595493 |
2014 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IRGM (human immunity-related GTPase) has an important function in eliminating Mycobacterium tuberculosis from host cells via autophagy.
|
24626347 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patient studies have shown genetic associations between tuberculosis and the autophagy gene IRGM, as well as with several genes indirectly involved in autophagy.
|
22683183 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent data suggest that autophagy is important for intracellular killing of Mycobacterium tuberculosis, and polymorphisms in the autophagy gene IRGM have been linked with susceptibility to tuberculosis (TB) among African-Americans, and with TB caused by particular M. tuberculosis genotypes in Ghana.
|
22879892 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.
|
21283700 |
2011 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IRGC is not involved in immunity, but the human IRGM gene plays a role in autophagy-targeted destruction of Mycobacterium tuberculosis (BCG) and Salmonella typhimurium.
|
20737271 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In 1.7 kb IRGM promoter region, only -1208A/G polymorphism is associated with susceptibility to TB.
|
20547146 |
2010 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results, including those of luciferase reporter gene assays with the IRGM variants -261C and -261T, suggest a role for IRGM and autophagy in protection of humans against natural infection with M. tuberculosis EUAM clades.
|
19750224 |
2009 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Three of these IFN-gamma-dependent mechanisms have been implicated in defense against M. tuberculosis: inducible nitric oxide synthase (iNOS), phagosome oxidase (phox), and the phagosome-associated GTPase LRG-47.
|
15322028 |
2004 |