IRGM, immunity related GTPase M, 345611

N. diseases: 57; N. variants: 13
Disease: Crohn's disease of the ileum ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. 21278745 2011
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 18438406 2008
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. 19165925 2008
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 17554261 2007